{"id":"W1996592764","doi":"10.1074/jbc.m302833200","title":"Calpains Mediate p53 Activation and Neuronal Death Evoked by DNA Damage","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Ottawa","funders":"Canadian Institutes of Health Research; Canadian Stroke Network; Heart and Stroke Foundation of Canada","keywords":"Calpain; Proteases; DNA damage; Calpastatin; Apoptosis; Cell biology; Programmed cell death; Caspase; Camptothecin; Biology; Chemistry; DNA; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658427,0.0005259527,0.0002499114,0.0002551694,0.0001862302,0.0003334701,0.0002506743,0.0005048186,0.0009904697],"category_scores_gemma":[0.0002330527,0.0001181605,0.0002015252,0.0001215513,0.0003192064,0.0004321398,0.0002540556,0.0007197315,0.0002609812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004620278,"about_ca_system_score_gemma":0.0001495963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006102674,"about_ca_topic_score_gemma":0.0008888845,"domain_scores_codex":[0.9998741,0.00001474065,0.000009864692,0.00002271104,0.00003022128,0.00004829494],"domain_scores_gemma":[0.9999129,0.00001377555,0.00002876855,0.000008276545,0.00001470186,0.00002169556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002740573,0.00004066384,0.0003103587,0.00006096656,0.000008738025,0.0003363028,0.00002065022,0.00004365327,0.9959759,0.0002134026,0.00007497298,0.002640333],"study_design_scores_gemma":[0.00005844938,0.0003130801,0.009632076,0.00001095822,0.00002230034,0.0009924936,0.00003677813,0.000826381,0.9861432,0.000363172,0.001597178,0.000003952449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97979,0.01369085,0.003956906,0.000336548,0.00006320511,0.00005377845,0.0001513966,0.00006709975,0.001890323],"genre_scores_gemma":[0.9937935,0.003409262,0.0009537136,0.00005204977,0.00002589045,0.00002302795,0.0001447652,0.0000037157,0.001594019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009904697,"threshold_uncertainty_score":0.003352225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302693866779812,"score_gpt":0.2307835716674951,"score_spread":0.217756632999697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}