{"id":"W1996594271","doi":"10.1161/01.cir.0000148176.33730.3f","title":"In Vivo Cardiac Gene Transfer of Kv4.3 Abrogates the Hypertrophic Response in Rats After Aortic Stenosis","year":2004,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Public Health Service; Heart and Stroke Foundation of Canada","keywords":"NFAT; Internal medicine; Medicine; Calcineurin; Muscle hypertrophy; Endocrinology; In vivo; Pressure overload; Myocyte; Downregulation and upregulation; Gene expression; Cardiac hypertrophy; Gene; Transplantation; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003200089,0.0008031743,0.0006759385,0.0004374684,0.0002503961,0.0002870155,0.0003523504,0.0004857405,0.001621055],"category_scores_gemma":[0.0002099606,0.0002786716,0.0004350593,0.0001902836,0.0007854028,0.0002928433,0.0002456623,0.00106555,0.0004023734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274516,"about_ca_system_score_gemma":0.0003579181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000638469,"about_ca_topic_score_gemma":0.000740867,"domain_scores_codex":[0.9997485,0.00003676193,0.00002565843,0.00004882026,0.00004433717,0.00009594472],"domain_scores_gemma":[0.9996051,0.0000436263,0.0001481537,0.00003442732,0.00003209073,0.0001366767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007907135,0.0001959018,0.0001367664,0.00004320761,0.000007934582,0.00005461891,0.00002904409,0.00005617365,0.9975521,0.00007101896,0.00003884103,0.001023669],"study_design_scores_gemma":[0.0003667884,0.006927508,0.006934439,0.00002826885,0.0001031465,0.0003811585,0.0001575374,0.001539766,0.9817234,0.0001262261,0.001692776,0.00001910912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972551,0.0004636377,0.001349511,0.0001300562,0.00007221842,0.00003383709,0.0001190695,0.0001190361,0.0004576075],"genre_scores_gemma":[0.9940069,0.0006663264,0.001946515,0.0001017691,0.00004762047,0.00011316,0.000297525,0.00005706151,0.002763029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001621055,"threshold_uncertainty_score":0.005423009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445701860822286,"score_gpt":0.2487694480472388,"score_spread":0.2343124294390159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}