{"id":"W1996620981","doi":"10.1038/sj.leu.2403703","title":"Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study","year":2005,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"National Cancer Institute; University of Alabama at Birmingham","keywords":"Lymphoblast; Methotrexate; Medicine; Progenitor cell; Leukemia; Lymphoblastic Leukemia; Acute lymphocytic leukemia; Antimetabolite; Internal medicine; Oncology; Vincristine; Chemotherapy; Pharmacology; Immunology; Stem cell; Cell culture; Biology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008616849,0.0006519854,0.001461601,0.001233207,0.00008316852,0.00004303114,0.0002144742,0.0003967437,0.00002582451],"category_scores_gemma":[0.0001506651,0.0005035968,0.00009653104,0.001183918,0.0002305415,0.0003157914,0.0002379906,0.0003973806,0.00001702194],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01128979,"about_ca_system_score_gemma":0.001907061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003512336,"about_ca_topic_score_gemma":0.0009947218,"domain_scores_codex":[0.9957446,0.000492801,0.001197792,0.001041172,0.0006424327,0.0008812333],"domain_scores_gemma":[0.9976943,0.0008419835,0.0004085171,0.0005555538,0.0001087459,0.0003908806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002127705,0.0009577361,0.97186,0.0001069402,0.0003534459,0.0003426167,0.002057627,0.0008718089,0.003522519,0.00001529181,0.000008878596,0.01777542],"study_design_scores_gemma":[0.04448504,0.004870353,0.9314429,0.00007115799,0.00104007,0.0009144225,0.0005608106,0.01402326,0.002078399,0.00002868822,0.00002274858,0.0004621934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961833,0.0007351759,0.0001463047,0.00010313,0.00003997962,0.002470883,0.0000296741,0.00007095396,0.0002206319],"genre_scores_gemma":[0.9903702,0.0005905583,0.008193002,0.00009351136,0.000194694,0.0002406237,0.00003895872,0.0001004454,0.0001780342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04235733,"threshold_uncertainty_score":0.9997416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03164074259694681,"score_gpt":0.3408437748785574,"score_spread":0.3092030322816106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}