{"id":"W1996638945","doi":"10.1210/en.2009-1195","title":"Regulation of the Matricellular Proteins CYR61 (CCN1) and NOV (CCN3) by Hypoxia-Inducible Factor-1α and Transforming-Growth Factor-β3 in the Human Trophoblast","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"Universitätsklinikum Essen","keywords":"CYR61; Trophoblast; Biology; Intracellular; Cell biology; Secretion; Extracellular; Hypoxia (environmental); Transforming growth factor; Internal medicine; Endocrinology; Placenta; CTGF; Growth factor; Chemistry; Biochemistry; Receptor; Fetus; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255248,0.0001864479,0.0001961885,0.00009327767,0.0001473392,0.00002572006,0.0003525243,0.0001739555,0.00005019594],"category_scores_gemma":[0.000150368,0.0001278793,0.00005100199,0.000179619,0.0003538446,0.00001148113,0.000153109,0.0004181854,0.000001709622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001279249,"about_ca_system_score_gemma":0.00004652037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004121836,"about_ca_topic_score_gemma":0.000544363,"domain_scores_codex":[0.9986073,0.0001821971,0.0002419271,0.0004063732,0.0001785988,0.0003836376],"domain_scores_gemma":[0.9992895,0.00005934483,0.0000887615,0.0004301811,0.00008099178,0.00005120958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003112738,0.00005141746,0.03539158,0.00002836245,0.00002145463,0.000002579091,0.0003101704,1.822309e-7,0.9620362,0.0007247817,0.00005443081,0.001347748],"study_design_scores_gemma":[0.0006584972,0.0002389742,0.2441407,0.000004571075,0.000007587388,0.00004619217,0.00009995513,0.000004240469,0.7502165,0.0002481268,0.004216199,0.0001184673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976994,0.0004175238,0.00008444774,0.000561723,0.00006418039,0.0007457181,0.00005704796,0.000007922259,0.0003620131],"genre_scores_gemma":[0.9995179,0.00005629851,0.00003868101,0.00002962544,0.00006766031,0.00005387675,0.00002296076,0.0000211322,0.0001918554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2118196,"threshold_uncertainty_score":0.5214765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376044539498408,"score_gpt":0.2613587306400326,"score_spread":0.2475982852450485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}