{"id":"W1996638945","doi":"10.1210/en.2009-1195","title":"Regulation of the Matricellular Proteins CYR61 (CCN1) and NOV (CCN3) by Hypoxia-Inducible Factor-1α and Transforming-Growth Factor-β3 in the Human Trophoblast","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"Universitätsklinikum Essen","keywords":"CYR61; Trophoblast; Biology; Intracellular; Cell biology; Secretion; Extracellular; Hypoxia (environmental); Transforming growth factor; Internal medicine; Endocrinology; Placenta; CTGF; Growth factor; Chemistry; Biochemistry; Receptor; Fetus; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001012968,0.0001624973,0.0001337188,0.0001287979,0.0001237432,0.0001895462,0.00006378441,0.0001563655,0.0004246975],"category_scores_gemma":[0.0001123403,0.0001074798,0.0001614325,0.0001007119,0.0001676133,0.0001074696,0.0001494037,0.0001794174,0.0001512275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003155118,"about_ca_system_score_gemma":0.0001560597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163117,"about_ca_topic_score_gemma":0.00103123,"domain_scores_codex":[0.9999218,0.00001973073,0.000007250222,0.00001647871,0.00001843843,0.00001625813],"domain_scores_gemma":[0.9999498,0.000009174369,0.00001508879,0.000005661789,0.000006773212,0.00001339257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000785581,0.000004976416,0.0002047942,0.00001350491,0.000001241969,0.00004154842,0.00001896445,0.00001713217,0.9993075,0.00002901845,0.000009443938,0.000273312],"study_design_scores_gemma":[0.00002152644,0.000202915,0.02922562,0.00000564352,0.0000141673,0.0004764526,0.00006847856,0.001205714,0.9666527,0.00005145028,0.002070009,0.000005293109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971831,0.001413573,0.0006000835,0.00004781653,0.000009169232,0.00001121855,0.0001224205,0.00001486819,0.0005976856],"genre_scores_gemma":[0.9967721,0.0006884315,0.0008531792,0.00002923863,0.000004188941,0.00002729892,0.0002824291,0.000005680087,0.00133746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163117,"threshold_uncertainty_score":0.00231272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376044539498408,"score_gpt":0.2613587306400326,"score_spread":0.2475982852450485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}