{"id":"W1996657370","doi":"10.1042/bj20041370","title":"Steady-state kinetics and inhibition of anaerobically purified human homogentisate 1,2-dioxygenase","year":2005,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Metal-Catalyzed Oxygenation Mechanisms","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Enzyme kinetics; Kinetics; Stereochemistry; Cleavage (geology); Enzyme; Tyrosine; Active site; Nuclear chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003838736,0.0003039269,0.0004716579,0.0001108092,0.00009463824,0.0003859462,0.0003340772,0.000349934,0.000605419],"category_scores_gemma":[0.00054629,0.0001938468,0.0002578274,0.0001891775,0.0002090345,0.0002284069,0.000141005,0.0005783408,0.0003369289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005665632,"about_ca_system_score_gemma":0.0002422871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119461,"about_ca_topic_score_gemma":0.0009850148,"domain_scores_codex":[0.9995887,0.00006362381,0.00002865749,0.000139837,0.00009029616,0.00008897394],"domain_scores_gemma":[0.999643,0.0001213989,0.00007077667,0.00003538109,0.00009464436,0.00003481257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005075545,0.0000748614,0.0007915612,0.00006115664,0.00001315539,0.00001728432,0.00003488298,0.0002105766,0.9954216,0.0001099095,0.00007583816,0.002681539],"study_design_scores_gemma":[0.0000141339,0.000266344,0.00525437,0.000003667662,0.00001482426,0.00005230544,0.00001546459,0.003085535,0.9902034,0.00005567657,0.001025183,0.000009067505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861923,0.004837148,0.006870606,0.00009544646,0.00004843958,0.0000482493,0.0008637853,0.000119308,0.0009247897],"genre_scores_gemma":[0.9921902,0.001153326,0.003373565,0.00003625259,0.00001893736,0.00005591655,0.001515427,0.00002476735,0.001631536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119461,"threshold_uncertainty_score":0.004110694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620468715568318,"score_gpt":0.2465523479422773,"score_spread":0.2303476607865942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}