{"id":"W1996681913","doi":"10.1074/jbc.m110.177014","title":"Autophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the α-Kinase Domain","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Israel Science Foundation; Natural Sciences and Engineering Research Council of Canada; Queen's University; Heart and Stroke Foundation of Canada; National Science Foundation","keywords":"Autophosphorylation; Allosteric regulation; Myosin light-chain kinase; Protein kinase domain; Biochemistry; Phosphorylation; Dephosphorylation; Chemistry; Kinase; Dictyostelium discoideum; Phosphatase; Binding site; Biology; Biophysics; Protein kinase A; Enzyme; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003903758,0.0002473618,0.0001005186,0.00005047124,0.0001192009,0.0001611186,0.0002054546,0.0001525389,0.0006840354],"category_scores_gemma":[0.00006763957,0.0001346559,0.0001542516,0.00005695199,0.000184223,0.0001240881,0.0001670782,0.0002341323,0.0002237212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003567665,"about_ca_system_score_gemma":0.0001995004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199288,"about_ca_topic_score_gemma":0.001454509,"domain_scores_codex":[0.9999791,0.000002571804,0.000001115229,0.000005569344,0.000007227221,0.00000440471],"domain_scores_gemma":[0.9999861,0.000003855346,0.000004447865,0.000001206654,9.302528e-7,0.000003463895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001588323,0.00006286219,0.00108741,0.0001208552,0.00001475527,0.0001881841,0.00003746599,0.005709788,0.9877002,0.001008019,0.000112742,0.003798971],"study_design_scores_gemma":[0.0002460341,0.0004895002,0.00633521,0.00003127138,0.0000469538,0.0004994692,0.00007684668,0.1254374,0.8595742,0.001098822,0.006139766,0.00002445572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944465,0.0005716927,0.002929069,0.00003401791,0.00001229247,0.00001154169,0.00004547344,0.00005122311,0.001898053],"genre_scores_gemma":[0.9981053,0.0002583388,0.001129811,0.00001305938,0.000001843723,0.000006355735,0.00005332566,0.00000455973,0.0004274126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199288,"threshold_uncertainty_score":0.002588511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464064293790927,"score_gpt":0.258037635045732,"score_spread":0.2433969921078227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}