{"id":"W1996691468","doi":"10.1002/jgm.691","title":"RD114‐pseudotyped retroviral vectors kill cancer cells by syncytium formation and enhance the cytotoxic effect of the TK/GCV gene therapy strategy","year":2004,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Syncytium; Cytotoxic T cell; Genetic enhancement; Viral vector; Gene; Virology; Cancer; Cancer research; Biology; Suicide gene; Virus; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000323192,0.0008528466,0.0004634448,0.0004355454,0.000193295,0.0004072216,0.000392579,0.0005904889,0.0009494432],"category_scores_gemma":[0.0001787155,0.0002070685,0.0005088545,0.0002543287,0.0002890547,0.0002813296,0.0002531127,0.001074947,0.0005907411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000503,"about_ca_system_score_gemma":0.0002586399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003733389,"about_ca_topic_score_gemma":0.0004377233,"domain_scores_codex":[0.9995943,0.00006867811,0.00005864134,0.00007866132,0.000148921,0.0000507804],"domain_scores_gemma":[0.9997963,0.00004198736,0.00005480876,0.00004600937,0.0000366647,0.00002420111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002769231,0.00002070364,0.00007626312,0.00003206398,0.000005206779,0.00002720716,0.00001092895,0.00005411435,0.9987508,0.00009522077,0.00004000887,0.0008596879],"study_design_scores_gemma":[0.000006919916,0.000134609,0.0005482095,0.000003363116,0.00001144573,0.0001611588,0.000004245701,0.0005064564,0.9972378,0.00001630812,0.00136668,0.000002842025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656608,0.00386753,0.02515667,0.0001367038,0.0001155834,0.0003379969,0.0008747193,0.0004166387,0.003433489],"genre_scores_gemma":[0.9678843,0.00171808,0.0227353,0.00006416068,0.0000209217,0.0002202979,0.001802781,0.00009250767,0.005461692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009494432,"threshold_uncertainty_score":0.003649592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008796165446855311,"score_gpt":0.2905850964341874,"score_spread":0.2817889309873321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}