{"id":"W1996691468","doi":"10.1002/jgm.691","title":"RD114‐pseudotyped retroviral vectors kill cancer cells by syncytium formation and enhance the cytotoxic effect of the TK/GCV gene therapy strategy","year":2004,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Syncytium; Cytotoxic T cell; Genetic enhancement; Viral vector; Gene; Virology; Cancer; Cancer research; Biology; Suicide gene; Virus; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001725567,0.0001936146,0.0002809772,0.00004278728,0.0001572191,0.00001040136,0.0005554436,0.00009196741,0.00003000948],"category_scores_gemma":[0.00006825587,0.00007935502,0.0000977724,0.0001859173,0.0003929384,0.00001118568,0.00005079136,0.0003026072,0.000001045011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005546543,"about_ca_system_score_gemma":0.0001715961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001021844,"about_ca_topic_score_gemma":0.00008087226,"domain_scores_codex":[0.9982339,0.0004994064,0.0004160123,0.0001264405,0.0004755569,0.0002486872],"domain_scores_gemma":[0.998813,0.00008250677,0.000438794,0.0004215112,0.0001691336,0.00007501274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002568438,0.00002357999,0.0001221819,0.0000182691,0.0001248921,0.000001251131,0.0002939995,0.0006729484,0.9917411,8.011432e-7,0.000966081,0.003466522],"study_design_scores_gemma":[0.002115254,0.008377354,0.0006316606,0.00005761291,0.00006631621,0.00006687935,0.00008462,0.00002247,0.9881261,0.00003787271,0.0003309694,0.0000829014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760484,0.02098662,0.0003054641,0.002004831,0.0002263102,0.0003818701,0.00001297419,0.00000244136,0.00003115562],"genre_scores_gemma":[0.9852773,0.0136336,0.00001145069,0.0004179164,0.0004990843,0.000007785839,0.000005032198,0.00002318401,0.0001246367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009228979,"threshold_uncertainty_score":0.3236004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008796165446855311,"score_gpt":0.2905850964341874,"score_spread":0.2817889309873321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}