{"id":"W1996691586","doi":"10.1016/s0888-7543(03)00173-3","title":"Discovery of a null mutation in a human trace amine receptor gene","year":2003,"lang":"en","type":"article","venue":"Genomics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Biology; Genetics; Gene; G protein-coupled receptor; Null allele; Mutation; Receptor; Allele; Mutant; Population; Signal transduction; Point mutation; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629446,0.00008052436,0.0001077624,0.00003448312,0.00002344155,0.00001070411,0.00006950252,0.00008438827,0.00002884331],"category_scores_gemma":[0.00002660365,0.00008437317,0.00005030839,0.00005233186,0.00001843965,0.00000349927,0.00001610855,0.00004132541,0.000002369105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002060122,"about_ca_system_score_gemma":0.00003984605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001672426,"about_ca_topic_score_gemma":0.00002648603,"domain_scores_codex":[0.9994159,0.00003778419,0.0001969046,0.0001754719,0.00004932102,0.0001246482],"domain_scores_gemma":[0.9997309,0.000004070371,0.0000747043,0.0001452354,0.00002397477,0.00002109339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001992409,0.00004128071,0.0001616789,0.000008223114,0.00001018285,0.000001312454,0.0001086029,0.0003718742,0.9983659,0.0005218824,0.00004584523,0.0003432589],"study_design_scores_gemma":[0.0003887371,0.0001412457,0.0001011032,0.000005285415,0.00000460373,0.000005407962,0.0001401471,0.00002725932,0.995024,0.0002814334,0.003781976,0.00009875071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907032,0.0004614624,0.0082946,0.000008073852,0.0001187525,0.0001059062,0.00001439718,0.000002403044,0.0002912041],"genre_scores_gemma":[0.9944406,0.00009305948,0.004778554,0.00002697483,0.00005756587,0.00000771272,0.00008314845,0.00001552119,0.0004969064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003737356,"threshold_uncertainty_score":0.3440638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0089600646827427,"score_gpt":0.2296351855402877,"score_spread":0.220675120857545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}