{"id":"W1996695017","doi":"10.1038/nm761","title":"PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest","year":2002,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":945,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; McGill University; Health Sciences Centre; McGill University Health Centre","funders":"","keywords":"Protein kinase B; Phosphorylation; Cell biology; Cancer research; Signal transduction; Transfection; PI3K/AKT/mTOR pathway; Biology; Nuclear transport; Kinase; Chemistry; Cytoplasm; Cell nucleus; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002869337,0.0006466379,0.0004563285,0.0006571947,0.0003672307,0.0005341817,0.0004298648,0.0004120419,0.004469288],"category_scores_gemma":[0.0002811663,0.0005083162,0.0003780871,0.000351989,0.0007549839,0.0004694434,0.0002911937,0.001561187,0.001047118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006478992,"about_ca_system_score_gemma":0.0007416797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00148727,"about_ca_topic_score_gemma":0.001570355,"domain_scores_codex":[0.9997539,0.00004038214,0.00002316445,0.00002954472,0.00005498763,0.00009816554],"domain_scores_gemma":[0.9997688,0.00005601149,0.0000459348,0.00003994091,0.00001293127,0.0000764123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001989313,0.0002570642,0.0002386617,0.0001304664,0.00002463483,0.0001500106,0.00002519033,0.0003252951,0.9920515,0.0008950628,0.0005903568,0.003322563],"study_design_scores_gemma":[0.0001905071,0.0005433412,0.002000648,0.000007632255,0.0000207674,0.000327102,0.00003380289,0.000982137,0.9927515,0.0002273911,0.002907984,0.000007257089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889385,0.001962946,0.001646241,0.000791257,0.0001871985,0.00005510384,0.0009573228,0.0003911894,0.005070187],"genre_scores_gemma":[0.9911678,0.001486126,0.001523344,0.0001537163,0.00003501227,0.00007427057,0.0008777947,0.00006563393,0.004616234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004469288,"threshold_uncertainty_score":0.01495123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008556818130101283,"score_gpt":0.2371092784375751,"score_spread":0.2285524603074739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}