{"id":"W1996707491","doi":"10.1159/000020641","title":"Animal Models of Alport Syndrome: Advancing the Prospects for Effective Human Gene Therapy","year":2000,"lang":"en","type":"review","venue":"Nephron Experimental Nephrology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Alport syndrome; Disease; Genetic enhancement; Human disease; Medicine; Kidney disease; Animal model; Bioinformatics; Biology; Glomerulonephritis; Gene; Pathology; Kidney; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001646112,0.0005738523,0.001205643,0.00008136442,0.0001993374,0.00001340148,0.0004801925,0.0007627293,0.00005058599],"category_scores_gemma":[0.000003310583,0.0003785973,0.0007455896,0.0001276983,0.0003802142,0.000008274818,0.0001181924,0.0002935602,0.000005554619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001015436,"about_ca_system_score_gemma":0.0001977563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003060908,"about_ca_topic_score_gemma":0.000004772698,"domain_scores_codex":[0.9977817,0.0001838427,0.000597529,0.0007462,0.0001602229,0.0005305054],"domain_scores_gemma":[0.9988655,0.00003789985,0.0004191705,0.0005457554,0.00004526763,0.0000864075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001758916,0.0007635768,0.000002424532,0.002043789,0.003550743,0.00007342519,0.0002831676,0.0003225467,0.6324385,0.0005307538,0.005163615,0.3530685],"study_design_scores_gemma":[0.001276801,0.005153518,0.000003147144,0.0003615296,0.0002431754,0.0006647861,0.00002281878,0.00001649148,0.08663159,0.0001053505,0.905033,0.0004877775],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03414316,0.9618748,0.00004075043,0.00001884982,0.0001747786,0.00318792,0.00006537558,0.00001935967,0.0004749644],"genre_scores_gemma":[0.03536794,0.9610604,0.0001586836,0.000343623,0.0003716332,0.001867851,0.0004846167,0.0001189212,0.0002263416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8998694,"threshold_uncertainty_score":0.9998666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697510144230286,"score_gpt":0.3162918197808186,"score_spread":0.2993167183385158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}