{"id":"W1996723116","doi":"10.1093/jac/dkh550","title":"A specific peptide inhibitor of the class B metallo-β-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display","year":2005,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Infections and bacterial resistance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Uncompetitive inhibitor; Peptide; Stenotrophomonas maltophilia; Biopanning; Phage display; Biochemistry; Non-competitive inhibition; Peptide library; Active site; Chemistry; Peptide sequence; Cyclic peptide; Enzyme; Biology; Bacteria; Pseudomonas aeruginosa; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008085684,0.0005316274,0.0003588272,0.0001557997,0.00008915622,0.0003467126,0.0002630489,0.0002953333,0.0007129438],"category_scores_gemma":[0.0001536478,0.0001019783,0.0002107048,0.0001923984,0.0001127496,0.0001235091,0.0001542655,0.000387401,0.0003542837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230436,"about_ca_system_score_gemma":0.0001164406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003905415,"about_ca_topic_score_gemma":0.0003970106,"domain_scores_codex":[0.9999074,0.00001403148,0.000006103919,0.00002416376,0.00002669058,0.00002160103],"domain_scores_gemma":[0.9999336,0.00001571694,0.00001967897,0.000003597181,0.00001185771,0.00001560751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008076892,0.00002049146,0.0001664317,0.00003068942,0.000004257009,0.00004766353,0.000007264622,0.0001161227,0.9982911,0.00001321983,0.00001809454,0.001203861],"study_design_scores_gemma":[0.00002434973,0.0004515547,0.00265735,0.000005534625,0.00002434993,0.0005460429,0.00001338445,0.001108251,0.9932326,0.00001314775,0.001917545,0.000005807543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903212,0.002739241,0.005320414,0.00007290465,0.00001380532,0.000062097,0.0004056883,0.00006825331,0.000996423],"genre_scores_gemma":[0.9885755,0.001650346,0.005608723,0.00006816751,0.0000131107,0.00005340903,0.0017387,0.0000215187,0.002270588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007129438,"threshold_uncertainty_score":0.00238502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008188769160746458,"score_gpt":0.2306229982071387,"score_spread":0.2224342290463922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}