{"id":"W1996723116","doi":"10.1093/jac/dkh550","title":"A specific peptide inhibitor of the class B metallo-β-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display","year":2005,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Infections and bacterial resistance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Uncompetitive inhibitor; Peptide; Stenotrophomonas maltophilia; Biopanning; Phage display; Biochemistry; Non-competitive inhibition; Peptide library; Active site; Chemistry; Peptide sequence; Cyclic peptide; Enzyme; Biology; Bacteria; Pseudomonas aeruginosa; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861013,0.0001709171,0.0002842062,0.0000492368,0.00009594778,0.00004903891,0.0002773223,0.0001266278,0.00008713912],"category_scores_gemma":[0.00002471794,0.0001224174,0.000385028,0.0001155349,0.0001213822,0.00002033227,0.00004612273,0.0001588429,0.00000240799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004814366,"about_ca_system_score_gemma":0.0001106932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001830095,"about_ca_topic_score_gemma":0.00002213958,"domain_scores_codex":[0.9988722,0.00007068391,0.0005290117,0.000176261,0.0001706319,0.0001812211],"domain_scores_gemma":[0.998867,0.00001481356,0.0005887354,0.0002861674,0.0001900909,0.00005315203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006471211,0.0001744768,0.0004326027,0.000008905823,0.0001308825,0.000004268104,0.00004784958,0.00009766155,0.9952248,0.000006729181,0.002791537,0.000433149],"study_design_scores_gemma":[0.00139175,0.00008612796,0.002994931,0.00006481315,0.00003843656,0.00005650792,0.00001311445,0.00001387174,0.9406323,0.000007345371,0.05457404,0.0001267989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978233,0.0002754322,0.0005684487,0.0003826181,0.0006970797,0.0001118116,0.00005167112,0.000002369588,0.00008729642],"genre_scores_gemma":[0.9949204,0.000477452,0.002245064,0.000374505,0.001602958,4.072503e-7,0.00000744261,0.00002906153,0.0003427178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05459255,"threshold_uncertainty_score":0.4992038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008188769160746458,"score_gpt":0.2306229982071387,"score_spread":0.2224342290463922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}