{"id":"W1996724759","doi":"10.1021/bi8012164","title":"The N1 Domain of Human Lactoferrin Is Required for Internalization by Caco-2 Cells and Targeting to the Nucleus","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Internalization; Lactoferrin; Transcytosis; Confocal microscopy; Caco-2; Chemistry; Fusion protein; Recombinant DNA; Transferrin receptor; Chimera (genetics); Nucleus; Transferrin; Cell culture; Fluorescence microscope; Cell biology; Green fluorescent protein; Antibody; Biophysics; Fluorescence; Biochemistry; Receptor; Cell; Biology; Endocytosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001687449,0.0002242786,0.0003593851,0.0001364107,0.0002958998,0.0004445376,0.0002072891,0.0003485978,0.001008882],"category_scores_gemma":[0.0003180459,0.0002258921,0.000270351,0.00009527645,0.0002711717,0.0003102249,0.0002725828,0.00033964,0.0006389198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007156108,"about_ca_system_score_gemma":0.0004714383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003090451,"about_ca_topic_score_gemma":0.003404673,"domain_scores_codex":[0.9998152,0.0000336194,0.00001727406,0.00003413782,0.00004932089,0.00005049354],"domain_scores_gemma":[0.9996681,0.00006660113,0.0001040121,0.00004058042,0.00003789011,0.00008279939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000601121,0.000009105227,0.0003365548,0.00001755147,0.000001319237,0.00008344624,0.00002079028,0.00002182298,0.9990544,0.00004858875,0.00001904863,0.0003273099],"study_design_scores_gemma":[0.00002360384,0.0001224953,0.03324811,0.00001333531,0.00001200618,0.001767047,0.0001672791,0.001212812,0.9604501,0.00006399208,0.002908596,0.00001066767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961523,0.0006944987,0.001937046,0.0001195093,0.00001006012,0.00001093729,0.0001507619,0.00004643884,0.0008784169],"genre_scores_gemma":[0.9956725,0.0002689484,0.002104878,0.00004707347,0.00000442387,0.0000217633,0.0005794922,0.00003099534,0.001270017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003090451,"threshold_uncertainty_score":0.006144881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746450286366766,"score_gpt":0.2902919912560156,"score_spread":0.2728274883923479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}