{"id":"W1996724759","doi":"10.1021/bi8012164","title":"The N1 Domain of Human Lactoferrin Is Required for Internalization by Caco-2 Cells and Targeting to the Nucleus","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Internalization; Lactoferrin; Transcytosis; Confocal microscopy; Caco-2; Chemistry; Fusion protein; Recombinant DNA; Transferrin receptor; Chimera (genetics); Nucleus; Transferrin; Cell culture; Fluorescence microscope; Cell biology; Green fluorescent protein; Antibody; Biophysics; Fluorescence; Biochemistry; Receptor; Cell; Biology; Endocytosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203381,0.0000693871,0.00008152544,0.000009327558,0.0004225649,0.00001887894,0.0001221947,0.00005795193,0.00001323373],"category_scores_gemma":[0.00004216846,0.00004897097,0.00003436545,0.00004856975,0.00006898709,0.00001791541,0.000024017,0.00005639824,0.000001748826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003676351,"about_ca_system_score_gemma":0.00001101467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006335967,"about_ca_topic_score_gemma":0.000004287312,"domain_scores_codex":[0.9993973,0.00002059608,0.0001963757,0.0001416712,0.00009479343,0.0001492059],"domain_scores_gemma":[0.999564,0.00005251821,0.00009677499,0.0001819484,0.00005783675,0.00004693538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007291884,0.00001662633,0.0001539363,0.00006483978,0.000003984311,1.867957e-7,0.0008366967,1.217573e-7,0.7468182,0.00004169217,0.2517864,0.0002044025],"study_design_scores_gemma":[0.0003403721,0.00004824914,0.00006850611,0.00004065917,0.000004491543,0.000003350281,0.0004016445,0.00006488569,0.8772402,0.00007891998,0.1216475,0.0000612401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941075,0.0003858713,0.0004597881,0.003927263,0.0001406411,0.0002463307,0.0001440761,0.00002048339,0.0005680223],"genre_scores_gemma":[0.9974526,0.00004850274,0.0005292989,0.001103363,0.0001705888,0.00001413387,0.00003737547,0.00001303976,0.0006310547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.130422,"threshold_uncertainty_score":0.325007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746450286366766,"score_gpt":0.2902919912560156,"score_spread":0.2728274883923479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}