{"id":"W1996745436","doi":"10.1371/journal.pone.0030215","title":"Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Toronto General Hospital; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Leukemia and Lymphoma Society of Canada; Cancer Research Society; Leukemia and Lymphoma Society","keywords":"Chromatin immunoprecipitation; Small interfering RNA; Signal transduction; Kinase; Biology; Apoptosis; Molecular biology; c-jun; Cancer research; Phosphorylation; Activator (genetics); Cell biology; Transcription factor; Gene expression; Transfection; Gene; Promoter; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510683,0.0004735583,0.0004491152,0.0002851134,0.0003088644,0.0004774245,0.0003912984,0.0004069174,0.0008776548],"category_scores_gemma":[0.00007388464,0.0001542739,0.0004569055,0.0002203636,0.0002596163,0.0004360585,0.0002529653,0.0007380943,0.0003470788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003753713,"about_ca_system_score_gemma":0.0001912089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001732383,"about_ca_topic_score_gemma":0.0003170584,"domain_scores_codex":[0.999898,0.00001732984,0.000006969014,0.00002233464,0.00002925657,0.00002621934],"domain_scores_gemma":[0.999966,0.000003103029,0.000009999977,0.000003984428,0.000006318164,0.0000105471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002555436,0.00007564466,0.0003326366,0.0002874755,0.00002042919,0.0004822881,0.00002984604,0.0001203213,0.9891664,0.0005982895,0.0001786911,0.008452553],"study_design_scores_gemma":[0.0001268509,0.001076464,0.01587065,0.00004908639,0.0001284818,0.003936664,0.00009598988,0.002862703,0.9562251,0.0009894305,0.01860675,0.00003175839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.901381,0.06768157,0.01743489,0.001890107,0.0002573482,0.0002047978,0.0007785324,0.0004376537,0.009934185],"genre_scores_gemma":[0.9778762,0.01362579,0.003832567,0.0002327829,0.00007340749,0.00008647899,0.0004961616,0.00002482064,0.00375176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008776548,"threshold_uncertainty_score":0.002936006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02629601783040783,"score_gpt":0.2102705584739759,"score_spread":0.1839745406435681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}