{"id":"W1996778202","doi":"10.1073/pnas.0407815101","title":"Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca <sup>2</sup> +-ATPases","year":2004,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Endoplasmic reticulum; SERCA; Immunoprecipitation; ER retention; Molecular biology; Biology; Complementary DNA; Phospholamban; Peptide sequence; Transfection; Epitope; Biochemistry; Cell biology; ATPase; Chemistry; Mutant; Antibody; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282704,0.0002713568,0.0002113144,0.00006758903,0.0001147966,0.000265811,0.0002078211,0.0002566286,0.0006199131],"category_scores_gemma":[0.0001801788,0.0001361521,0.0002663029,0.0001022515,0.0002515314,0.0002219023,0.0001919121,0.0002977866,0.0006494255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941931,"about_ca_system_score_gemma":0.0002415665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004555871,"about_ca_topic_score_gemma":0.0008297548,"domain_scores_codex":[0.9998877,0.00002025645,0.00001729103,0.00002562263,0.00002676375,0.00002235295],"domain_scores_gemma":[0.9997813,0.00003970367,0.00009106696,0.00002180831,0.00002393756,0.00004212189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000444406,0.000006568863,0.0001165567,0.00001515977,0.00000174809,0.0000310188,0.000005905218,0.00002214287,0.99946,0.00004819351,0.000006894398,0.0002413047],"study_design_scores_gemma":[0.00003010933,0.00009847831,0.006759836,0.000009375181,0.00001104894,0.0004838617,0.0000237961,0.0009046289,0.9888432,0.00004305067,0.002786861,0.000005777672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996639,0.0007535562,0.001857743,0.00006669608,0.00001142486,0.00001262923,0.0001231259,0.00002265976,0.0005131557],"genre_scores_gemma":[0.9946136,0.0004730303,0.002367085,0.00003636062,0.000009001891,0.00002599954,0.0007887378,0.00002178278,0.001664401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006199131,"threshold_uncertainty_score":0.002860129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06068925302644202,"score_gpt":0.3151577374993034,"score_spread":0.2544684844728614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}