{"id":"W1996779865","doi":"10.1038/nsmb882","title":"The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR","year":2004,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":357,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Cyclic nucleotide-binding domain; Cystic fibrosis transmembrane conductance regulator; Chemistry; ΔF508; Endoplasmic reticulum; Transmembrane domain; Folding (DSP implementation); Protein folding; Mutagenesis; Mutant; Biochemistry; Transmembrane protein; Mutation; Biophysics; Amino acid; Cell biology; Peptide sequence; Biology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404367,0.0001726491,0.0002387007,0.0001344728,0.0001989495,0.00002156226,0.0001176864,0.0001945386,0.00002088122],"category_scores_gemma":[0.0005755375,0.0001139739,0.0001134433,0.0002328423,0.0003961737,0.00007765127,0.0000469636,0.0005549632,0.000001659852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007851977,"about_ca_system_score_gemma":0.0001250135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000615779,"about_ca_topic_score_gemma":0.0001042066,"domain_scores_codex":[0.9987612,0.0001121946,0.0002877311,0.0002913545,0.0002425917,0.0003049044],"domain_scores_gemma":[0.999024,0.0003128544,0.000116377,0.0002041813,0.000233583,0.0001089509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005743084,0.000009044291,0.0009064588,0.00004935676,0.0001109944,0.00003350546,0.0002058722,0.0001195814,0.9681231,0.02595066,0.00001178816,0.003905356],"study_design_scores_gemma":[0.006821698,0.00237716,0.394685,0.0003946078,0.0002105329,0.002828154,0.001200902,0.0003277564,0.1975544,0.3888923,0.004118476,0.0005890136],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836042,0.004195902,0.006156462,0.005147154,0.0002781641,0.000450039,0.00007919956,0.00002570217,0.00006317412],"genre_scores_gemma":[0.9682199,0.00001761067,0.03126924,0.0001699824,0.00007864933,0.00001614747,0.0002062464,0.00001575376,0.000006499587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7705687,"threshold_uncertainty_score":0.464772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003456809102838618,"score_gpt":0.3237522831019178,"score_spread":0.3202954739990792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}