{"id":"W1996844726","doi":"10.1016/j.etp.2006.01.008","title":"Sanguinarine overcomes P-glycoprotein-mediated multidrug-resistance via induction of apoptosis and oncosis in CEM-VLB 1000 cells","year":2006,"lang":"en","type":"article","venue":"Experimental and Toxicologic Pathology","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Sanguinarine; Apoptosis; Programmed cell death; Biology; Molecular biology; Cell culture; Multiple drug resistance; Annexin; Blot; Cell biology; Biochemistry; Alkaloid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547686,0.0001751102,0.0004220897,0.0001795749,0.0000549084,0.000006966468,0.00005276656,0.0001895538,0.0001560101],"category_scores_gemma":[0.0000238764,0.0001445336,0.00004286869,0.0002076142,0.0003430636,0.00006862012,0.0001242742,0.0002069116,0.000006974067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007179194,"about_ca_system_score_gemma":0.00002289696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003837071,"about_ca_topic_score_gemma":0.00005094729,"domain_scores_codex":[0.9987806,0.00009877994,0.0003174695,0.0003594399,0.0001469065,0.0002967771],"domain_scores_gemma":[0.9995841,0.00006995117,0.00008531966,0.0001469698,0.00003071789,0.0000829672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002872398,0.0008243988,0.01423157,0.0000507639,0.00001093111,0.0001086555,0.0002149607,9.238992e-7,0.9824861,0.00009601004,0.0001522791,0.001536152],"study_design_scores_gemma":[0.002374226,0.001079322,0.09166999,0.00003237365,0.000010079,0.00008978567,0.0004329938,0.00003175785,0.9033494,0.0001005614,0.0006940154,0.0001354734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993679,0.002869279,0.00001080426,0.0003754966,0.00007538332,0.0004488353,0.00001257245,0.00002835228,0.002500226],"genre_scores_gemma":[0.9974166,0.0001983863,0.001025069,0.0001233757,0.00006543917,0.00006625435,0.00002654684,0.00001272825,0.001065602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0791367,"threshold_uncertainty_score":0.5893908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270051576358044,"score_gpt":0.2791483275276525,"score_spread":0.266447811764072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}