{"id":"W1996859443","doi":"10.1038/nchembio.238","title":"NMR spectroscopy brings invisible protein states into focus","year":2009,"lang":"en","type":"review","venue":"Nature Chemical Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":430,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Conformational isomerism; Folding (DSP implementation); Function (biology); Excited state; Nuclear magnetic resonance spectroscopy; Protein function; Chemistry; Molecular dynamics; Spectroscopy; Protein folding; Protein structure; Computational biology; Computational chemistry; Physics; Biology; Stereochemistry; Biochemistry; Evolutionary biology; Atomic physics; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001660949,0.001314933,0.001651171,0.001715341,0.0004020906,0.001184065,0.001507916,0.002311345,0.001821074],"category_scores_gemma":[0.001651403,0.0005204786,0.0003797142,0.001819637,0.002069487,0.003107083,0.001135997,0.002682935,0.001987984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00111781,"about_ca_system_score_gemma":0.0009690491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009659399,"about_ca_topic_score_gemma":0.001970479,"domain_scores_codex":[0.9997447,0.00004659053,0.00002570398,0.00005398981,0.0001048259,0.00002410012],"domain_scores_gemma":[0.9990202,0.0005495517,0.00007074121,0.00005320784,0.0002447519,0.00006150243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007601459,0.00007236312,0.000136587,0.005967305,0.0000495422,0.0002048917,0.00004603927,0.0003991296,0.005575125,0.0127023,0.04383573,0.9309349],"study_design_scores_gemma":[0.00001969123,0.0000523898,0.0002899887,0.001010694,0.00005759504,0.0008299221,0.00004248704,0.0002445462,0.002718764,0.007563499,0.9871416,0.00002891143],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001524221,0.9940611,0.001710442,0.0008748829,0.00106534,0.000004723613,0.00001536296,0.00002424227,0.002091592],"genre_scores_gemma":[0.001232844,0.993182,0.001456405,0.001058574,0.001144801,0.0000139027,0.00002805422,0.000006470431,0.001876986],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002311345,"threshold_uncertainty_score":0.008783996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005686219976341078,"score_gpt":0.300158994741516,"score_spread":0.294472774765175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}