{"id":"W1996876030","doi":"10.1021/ml1000454","title":"KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue","year":2010,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"University of California, Los Angeles","keywords":"Biotinylation; Curcumin; Acetone; Chemistry; Cytotoxic T cell; Covalent bond; Peptide; Biochemistry; Combinatorial chemistry; Cell biology; Biology; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005739049,0.0004073781,0.0001647414,0.0001476443,0.0001750139,0.00009848134,0.0001898951,0.000218867,0.001922616],"category_scores_gemma":[0.00007565617,0.0001312645,0.0001688014,0.0001240548,0.0001917344,0.0001468212,0.0001612723,0.000312053,0.0006754877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002281888,"about_ca_system_score_gemma":0.0001597508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008420347,"about_ca_topic_score_gemma":0.0009836658,"domain_scores_codex":[0.999938,0.00001165667,0.000003084099,0.00001398692,0.00001777854,0.0000154227],"domain_scores_gemma":[0.999971,0.000004030009,0.00001048522,0.000003266665,0.000004179391,0.000006966393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006678831,0.000004787216,0.00006158358,0.0000267678,0.0000022599,0.00003843125,0.000004500897,0.00002466207,0.9991115,0.00003847973,0.00002215622,0.0005980082],"study_design_scores_gemma":[0.000009180962,0.0001527019,0.001760765,0.000002856209,0.000007883365,0.0003114043,0.00001031424,0.0001267821,0.9945861,0.00001606131,0.003012482,0.00000347799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910032,0.002138264,0.003659204,0.0001374219,0.00002598883,0.00003521561,0.0003115129,0.0001068065,0.002582439],"genre_scores_gemma":[0.9911446,0.0009520373,0.002714807,0.00004347417,0.000006572237,0.00004197314,0.0005350986,0.00001489149,0.004546427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001922616,"threshold_uncertainty_score":0.006431758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006881690175572271,"score_gpt":0.2446398384875026,"score_spread":0.2377581483119303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}