{"id":"W1996889416","doi":"10.1021/ml200084n","title":"Agonists for the Chemokine Receptor CXCR4","year":2011,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Agonist; Chimera (genetics); Chemokine receptor; Receptor; Chemokine; CXCR4; Chemistry; Partial agonist; Peptide; Chemotaxis; G protein-coupled receptor; Cell biology; Pharmacology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290526,0.0002911113,0.000252402,0.0001463926,0.0001774183,0.000329862,0.0002331243,0.0003007322,0.00182431],"category_scores_gemma":[0.0001925972,0.0001430872,0.0002940065,0.0001101369,0.0001652213,0.0002372782,0.0002515393,0.000763683,0.0004842463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003794952,"about_ca_system_score_gemma":0.0002426226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000194311,"about_ca_topic_score_gemma":0.0003695234,"domain_scores_codex":[0.9997613,0.0000865179,0.00001710295,0.00002574808,0.00005707898,0.0000522336],"domain_scores_gemma":[0.9999288,0.00001830297,0.00001742272,0.00000991545,0.000009510656,0.00001600905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001044842,0.00004595516,0.0003153587,0.00008714745,0.0000120256,0.00005854108,0.00002547629,0.0003511012,0.9927121,0.001214264,0.0002042959,0.004869239],"study_design_scores_gemma":[0.0001057393,0.001611172,0.00179739,0.00002612526,0.00004916351,0.0007855644,0.00004164876,0.002232266,0.9775814,0.0003408391,0.01540607,0.00002256113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703821,0.007740618,0.0142509,0.0005977605,0.0001133762,0.0001892086,0.0004019636,0.0001558161,0.006168158],"genre_scores_gemma":[0.977645,0.003450814,0.0148184,0.0003146341,0.00003048999,0.0001170919,0.0003213278,0.00001465554,0.003287459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00182431,"threshold_uncertainty_score":0.006102979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03507979467089059,"score_gpt":0.2537756671876958,"score_spread":0.2186958725168052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}