{"id":"W1996924573","doi":"10.1074/jbc.m109.040097","title":"Mycobacterium tuberculosis Origin of Replication and the Promoter for Immunodominant Secreted Antigen 85B Are the Targets of MtrA, the Essential Response Regulator","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Chromatin immunoprecipitation; Chromatin; Biology; Origin of replication; Cell biology; Gene; Plasmid; Molecular biology; Genetics; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132459,0.0003751023,0.00023698,0.0002358473,0.0002001682,0.000342933,0.0002067215,0.0003883476,0.0007341268],"category_scores_gemma":[0.0002729539,0.0001616413,0.0001614993,0.0001530902,0.0002531583,0.0001245546,0.0002645307,0.0004321933,0.0008766953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006985,"about_ca_system_score_gemma":0.0002255812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002775958,"about_ca_topic_score_gemma":0.0002134074,"domain_scores_codex":[0.999806,0.00002906179,0.000009151414,0.00004704722,0.00007656813,0.00003220275],"domain_scores_gemma":[0.9998313,0.00002275922,0.00007502356,0.00001821175,0.00001829315,0.00003453216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005035285,0.00001170596,0.0005116233,0.00004164056,0.000001568149,0.0000519161,0.00001359594,0.00002134112,0.9976248,0.0001006924,0.00001725241,0.001553666],"study_design_scores_gemma":[0.00002560755,0.0003246835,0.04644283,0.00002522988,0.0000203035,0.002421601,0.00007312172,0.0008952395,0.9414248,0.0003490273,0.007989329,0.000008163229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823301,0.007939639,0.007404688,0.0001988582,0.00003469192,0.00003260736,0.0003756704,0.0001479657,0.001535795],"genre_scores_gemma":[0.9911247,0.001701549,0.004060561,0.00006343087,0.00002192326,0.00002733274,0.0009487942,0.00001856625,0.002033036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007341268,"threshold_uncertainty_score":0.00245589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192388632074549,"score_gpt":0.3146897954921779,"score_spread":0.2927659091714324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}