{"id":"W1996924573","doi":"10.1074/jbc.m109.040097","title":"Mycobacterium tuberculosis Origin of Replication and the Promoter for Immunodominant Secreted Antigen 85B Are the Targets of MtrA, the Essential Response Regulator","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Chromatin immunoprecipitation; Chromatin; Biology; Origin of replication; Cell biology; Gene; Plasmid; Molecular biology; Genetics; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004690024,0.0001220415,0.0005129524,0.00002015953,0.00009260648,0.000008986936,0.0002989764,0.0002283984,0.00005660376],"category_scores_gemma":[0.007466853,0.00004251373,0.0002861483,0.00009473915,0.0009771272,0.00002411212,0.00007705806,0.000545482,3.568077e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001665215,"about_ca_system_score_gemma":0.00008987759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001222963,"about_ca_topic_score_gemma":8.725535e-7,"domain_scores_codex":[0.9984351,0.000322905,0.0006776988,0.0001757554,0.0001829486,0.0002055306],"domain_scores_gemma":[0.9966984,0.001561484,0.0007139399,0.0005200094,0.000420593,0.00008556539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01226933,0.00006433907,0.01265935,0.00007901756,0.0001835057,0.000003124313,0.00007379971,3.236436e-7,0.9735849,0.00003364959,0.0004915709,0.0005570503],"study_design_scores_gemma":[0.00180243,0.0003487814,0.3475558,0.00006938261,0.00009356465,0.0004268246,0.0001901734,0.0001039637,0.6453787,0.00036796,0.003604057,0.00005836361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754564,0.000981428,0.00004576403,0.02301554,0.00006881489,0.0003773826,0.00002714333,0.000003568533,0.0000239525],"genre_scores_gemma":[0.9985917,0.0005602143,0.0003021446,0.0001735752,0.0002956714,0.00001927808,0.000009030905,0.000007112039,0.00004127729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3348965,"threshold_uncertainty_score":0.893906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192388632074549,"score_gpt":0.3146897954921779,"score_spread":0.2927659091714324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}