{"id":"W1996925493","doi":"10.1016/j.vascn.2010.06.005","title":"Arrhythmogenic liability screening in cardiovascular safety pharmacology: Commonality between non-clinical safety pharmacology and clinical thorough QT (TQT) studies","year":2010,"lang":"en","type":"review","venue":"Journal of Pharmacological and Toxicological Methods","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"L'Alliance Boviteq; Université de Montréal","funders":"","keywords":"Safety pharmacology; Clinical pharmacology; QT interval; Medicine; Pharmacology; Cardiology; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad","sts","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0346071,0.001399078,0.01627046,0.0004075617,0.0004237928,0.00003496796,0.0006193622,0.003938926,0.0004309549],"category_scores_gemma":[0.004291192,0.0008693617,0.005950638,0.0008182951,0.003663745,0.0002113842,0.001313869,0.01450377,0.00000925784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003179961,"about_ca_system_score_gemma":0.0007032441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002708528,"about_ca_topic_score_gemma":0.000001222781,"domain_scores_codex":[0.9671678,0.02226228,0.006832403,0.001812747,0.0006076213,0.001317161],"domain_scores_gemma":[0.9674413,0.02764086,0.002443567,0.0004671535,0.0005616751,0.001445444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003614062,0.0012711,0.003886565,0.001893409,0.0169984,0.004821352,0.00002751706,0.000007363699,0.0002055941,0.00002181838,0.0006778017,0.966575],"study_design_scores_gemma":[0.01035596,0.006108835,0.04380095,0.001274619,0.04437615,0.005848804,0.00003967538,0.00005447459,0.00009717557,0.0006754077,0.8862892,0.001078694],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0568595,0.9335389,0.001256407,0.001532142,0.003796269,0.002708098,0.00007997659,0.00006474772,0.0001639876],"genre_scores_gemma":[0.003705111,0.9543145,0.03170981,0.001680362,0.008341395,0.0001067634,0.00002415973,0.00006394374,0.00005399909],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9654963,"threshold_uncertainty_score":0.999876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2175392969036154,"score_gpt":0.5559649518382301,"score_spread":0.3384256549346147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}