{"id":"W1996947529","doi":"10.1002/adsc.200800447","title":"Efficient Synthesis of γ,δ‐Alkynyl‐β‐amino Acid Derivatives by a New Copper‐Catalyzed Amine‐Alkyne‐Alkyne Addition Reaction","year":2008,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McGill University","keywords":"Alkyne; Chemistry; Amine gas treating; Catalysis; Copper; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002449712,0.0006753512,0.0003178877,0.0002777303,0.0001768269,0.0002016665,0.0003613278,0.0003181099,0.0008881552],"category_scores_gemma":[0.0002034892,0.0003007789,0.0002104337,0.000195918,0.0002093732,0.0003570217,0.0002689614,0.0005426356,0.0004507988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002538984,"about_ca_system_score_gemma":0.0003950212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005107489,"about_ca_topic_score_gemma":0.0009653493,"domain_scores_codex":[0.9998599,0.00002167531,0.00001725175,0.00002993426,0.00004118164,0.00002993569],"domain_scores_gemma":[0.9998876,0.00001535987,0.0000298247,0.00001417771,0.00002251643,0.00003059432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004923104,0.00002184185,0.00007106003,0.0001085605,0.00001497294,0.0002348928,0.00003962444,0.0002282435,0.9949414,0.000354125,0.00007873381,0.003857365],"study_design_scores_gemma":[0.00002171687,0.0001840337,0.0002955138,0.000005061364,0.00001685099,0.0002557464,0.000009164666,0.0004127269,0.9957023,0.00004873312,0.003037635,0.000010455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446386,0.004603388,0.03917961,0.0001566343,0.0001612018,0.0003111514,0.0004264227,0.0002912942,0.01023163],"genre_scores_gemma":[0.9714838,0.002852848,0.02124546,0.00005217596,0.00001854201,0.000110669,0.0002040528,0.00003217483,0.004000336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008881552,"threshold_uncertainty_score":0.002971232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007132361479861512,"score_gpt":0.2211087676173681,"score_spread":0.2139764061375066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}