{"id":"W1996948365","doi":"10.1021/bi101286d","title":"Loss of Membrane Targeting of Vangl Proteins Causes Neural Tube Defects","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Pepstatin; Chemistry; Chromatography; Biochemistry; Sephadex; Isoelectric focusing; Cathepsin D; Gel electrophoresis; Polyacrylamide gel electrophoresis; Enzyme; Protease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940651,0.0001822867,0.0002143938,0.00003456412,0.00003953298,0.00001013176,0.000377077,0.000298668,0.00009651183],"category_scores_gemma":[0.0006941875,0.0001739794,0.0001413578,0.0001226932,0.0002843073,0.000003828895,0.0002230995,0.0002425062,0.000003662614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008638749,"about_ca_system_score_gemma":0.0001794057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005988933,"about_ca_topic_score_gemma":0.0000167898,"domain_scores_codex":[0.9987249,0.00003057934,0.0002979307,0.0003524854,0.0002708456,0.0003232266],"domain_scores_gemma":[0.9988921,0.00002349741,0.0001527506,0.0005549879,0.0002523961,0.0001243189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000675119,0.00009940202,0.01881015,0.0003042462,0.00003707826,0.000005167669,0.00001744697,0.000005029381,0.9800886,0.000005335344,0.0004320195,0.000128036],"study_design_scores_gemma":[0.0003524785,0.0001047503,0.00127782,0.00001897281,0.00001117129,0.00001615465,0.00004257043,0.00002168571,0.997231,0.000006515562,0.0007478115,0.00016908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985948,0.0003120775,0.00002006261,0.00004117301,0.0001140169,0.0001834168,0.00008137592,0.00001263305,0.0006404215],"genre_scores_gemma":[0.9985294,0.00002574917,0.0005550574,0.0000155194,0.0002423307,0.00001710028,0.0001505959,0.00003059552,0.0004336346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01753234,"threshold_uncertainty_score":0.7094674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008965918203645321,"score_gpt":0.2659679508557585,"score_spread":0.2570020326521132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}