{"id":"W1996963479","doi":"10.2174/156800912799277511","title":"The Blood-Brain Barrier: Its Influence in the Treatment of Brain Tumors Metastases","year":2012,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canada Research Chairs","keywords":"Medicine; Blood–brain barrier; Chemotherapy; Brain tumor; Brain metastasis; Radiation therapy; Oncology; Brain cancer; Cancer; Internal medicine; Pathology; Central nervous system; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006325328,0.0007457798,0.001987355,0.0002187082,0.0001774538,0.00004511555,0.0004408171,0.0001018856,0.0001202571],"category_scores_gemma":[0.0001984195,0.0003337475,0.0008749513,0.000580753,0.0001745079,0.00009158134,0.00005740396,0.0003288002,0.00004416336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004207122,"about_ca_system_score_gemma":0.0006466778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002429834,"about_ca_topic_score_gemma":0.0002902223,"domain_scores_codex":[0.9965941,0.0005867886,0.0009971772,0.000534091,0.0005903959,0.000697394],"domain_scores_gemma":[0.9965249,0.00159712,0.000636005,0.0008933996,0.0001229612,0.0002255704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000019026,0.002122859,0.001323381,0.005029379,0.0008338817,0.00007823426,0.001053792,0.000003543664,0.00000179965,0.0002748329,0.003928063,0.9853312],"study_design_scores_gemma":[0.001273868,0.0002074349,0.000616712,0.008395699,0.004390321,0.00003915181,0.00006249934,0.000001381769,0.0001286855,0.00001267642,0.9845974,0.0002741209],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004849294,0.9893093,1.230655e-7,0.001222351,0.0006886495,0.003139707,0.0007040794,0.00002222321,0.00006434081],"genre_scores_gemma":[0.003499228,0.9915388,0.000008320391,0.0001085128,0.0003881631,0.004026061,0.0002333114,0.00005790186,0.0001396895],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9850571,"threshold_uncertainty_score":0.9999114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05824059173052305,"score_gpt":0.3778907565616442,"score_spread":0.3196501648311212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}