{"id":"W1996995902","doi":"10.1038/nm1234","title":"Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo","year":2005,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":488,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"National Institute on Aging; Wellcome Trust","keywords":"Long-term potentiation; In vivo; Synaptic plasticity; Antibody; Hippocampus; Immunotherapy; Alzheimer's disease; Monoclonal antibody; Immunology; Chemistry; Neuroscience; Biology; Pharmacology; Medicine; Biochemistry; Immune system; Disease; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002090719,0.0003626769,0.000638246,0.0003806027,0.00008795686,0.00001297059,0.0001859901,0.0003414702,0.001485557],"category_scores_gemma":[0.0001917124,0.0002410625,0.0001204963,0.0004902487,0.0003276987,0.0001488173,0.00003541114,0.001082202,0.000080481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002842206,"about_ca_system_score_gemma":0.0001732909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001954688,"about_ca_topic_score_gemma":0.0001344382,"domain_scores_codex":[0.9974796,0.00009181538,0.0003474556,0.0004707726,0.0009151092,0.000695246],"domain_scores_gemma":[0.9987951,0.0001491455,0.00009227781,0.0003790865,0.00009501722,0.0004893699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0380009,0.01470085,0.4512601,0.002442033,0.04616638,0.01328643,0.007081655,0.0001088504,0.2826408,0.00548777,0.03264976,0.1061745],"study_design_scores_gemma":[0.09336738,0.00939645,0.5997385,0.00714425,0.00247166,0.0008861298,0.001882069,0.002017648,0.2120491,0.001276161,0.06757873,0.002191881],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542075,0.02957016,0.00002148847,0.01073052,0.0001333821,0.001432385,0.00002700843,0.0001171581,0.003760383],"genre_scores_gemma":[0.9964225,0.0007213837,0.0002217796,0.001426517,0.0005448371,0.0001346523,0.00004655575,0.00005184468,0.0004299168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1484784,"threshold_uncertainty_score":0.9994272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620889515851833,"score_gpt":0.3182884015828656,"score_spread":0.3020795064243473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}