{"id":"W1996995902","doi":"10.1038/nm1234","title":"Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo","year":2005,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":488,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"National Institute on Aging; Wellcome Trust","keywords":"Long-term potentiation; In vivo; Synaptic plasticity; Antibody; Hippocampus; Immunotherapy; Alzheimer's disease; Monoclonal antibody; Immunology; Chemistry; Neuroscience; Biology; Pharmacology; Medicine; Biochemistry; Immune system; Disease; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002688038,0.0006703525,0.0006452141,0.0004387391,0.0003333604,0.0004411247,0.0004288414,0.0006672684,0.001547043],"category_scores_gemma":[0.0002427855,0.0002517613,0.0004642905,0.0002019905,0.0004650816,0.0004924017,0.0001731706,0.001795169,0.000617639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394986,"about_ca_system_score_gemma":0.0003803917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002861033,"about_ca_topic_score_gemma":0.000304082,"domain_scores_codex":[0.9998115,0.00002778246,0.00001592676,0.00003614287,0.00004351898,0.00006511011],"domain_scores_gemma":[0.9998271,0.00003800347,0.00003087013,0.00003077991,0.00002138556,0.00005197194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008706775,0.0006143062,0.0001027086,0.00006215919,0.00005454558,0.00009589833,0.00002664068,0.0001857113,0.9930493,0.0003260557,0.0003309257,0.004281067],"study_design_scores_gemma":[0.0004138185,0.003481514,0.001960789,0.00001296364,0.0000791819,0.0007542202,0.00004503816,0.001464963,0.9888861,0.0007292589,0.002160423,0.0000116741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936098,0.001148026,0.002292068,0.0003252875,0.0002756215,0.00005424707,0.0001241076,0.0001471332,0.002023603],"genre_scores_gemma":[0.9938681,0.001357844,0.001385387,0.0002034657,0.0001252972,0.00007177538,0.0002225149,0.0000393509,0.002726246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547043,"threshold_uncertainty_score":0.005175352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620889515851833,"score_gpt":0.3182884015828656,"score_spread":0.3020795064243473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}