{"id":"W1997012847","doi":"10.1021/la1026224","title":"Phase Behavior of Ketoprofen−Poly(lactic acid) Drug Particles Formed by Rapid Expansion of Supercritical Solutions","year":2010,"lang":"en","type":"article","venue":"Langmuir","topic":"Phase Equilibria and Thermodynamics","field":"Engineering","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Supercritical fluid; Amorphous solid; Lactic acid; Chemical engineering; Naproxen; Ketoprofen; Dissolution; Micronization; Solubility; Materials science; Phase (matter); Particle size; Chemistry; Organic chemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001431494,0.0001725699,0.0001222875,0.0002148586,0.0001445409,0.0002197802,0.0001142179,0.0001494337,0.0005940755],"category_scores_gemma":[0.0002811436,0.0001162003,0.0001461427,0.0001035611,0.0002463958,0.0002444952,0.0001048557,0.0002651883,0.0001979142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021851,"about_ca_system_score_gemma":0.0001697887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008619603,"about_ca_topic_score_gemma":0.0008651126,"domain_scores_codex":[0.9998513,0.00002143316,0.000007660859,0.00002614079,0.00006682726,0.00002650931],"domain_scores_gemma":[0.9998711,0.00004792239,0.00002748222,0.000008237646,0.00003170495,0.00001340488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007542915,0.00001420775,0.0003877055,0.00004199554,0.000007343375,0.00003962517,0.00004715102,0.00024965,0.9964354,0.0001043851,0.00002724897,0.002569879],"study_design_scores_gemma":[0.00001068119,0.0001664474,0.002490934,0.000003671933,0.00000637878,0.00005225137,0.00001706737,0.001763321,0.9946872,0.00003250264,0.000765308,0.000004277449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954847,0.0008497143,0.002580615,0.00001911387,0.00001279706,0.00003173695,0.00007234082,0.00003220518,0.0009167913],"genre_scores_gemma":[0.9974259,0.0004249354,0.001300934,0.00001168684,0.000006763071,0.00002164773,0.0001088018,0.00001593312,0.0006833992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008619603,"threshold_uncertainty_score":0.001987398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374436531010021,"score_gpt":0.2586322317597951,"score_spread":0.2448878664496948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}