{"id":"W1997043298","doi":"10.1097/00001503-200208000-00004","title":"Mechanisms of general anesthesia","year":2002,"lang":"en","type":"article","venue":"Current Opinion in Anaesthesiology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"GABAA receptor; Neuroscience; Allosteric regulation; Receptor; Anesthetic; GABAergic; Neuroactive steroid; Medicine; General anesthetics; gamma-Aminobutyric acid; Pharmacology; Pregnanolone; GABA receptor antagonist; Bicuculline; Biology; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002065013,0.0001463838,0.0002548374,0.0003576272,0.0000746731,0.000008849798,0.0005471378,0.00007682794,0.0002896257],"category_scores_gemma":[0.0002205654,0.000130161,0.00006591766,0.0006164679,0.0004149861,0.0001119089,0.00007893261,0.0003105601,0.0001674954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000179658,"about_ca_system_score_gemma":0.00002414782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003143437,"about_ca_topic_score_gemma":1.609731e-7,"domain_scores_codex":[0.997876,0.0005595284,0.0003406386,0.0005279551,0.000232493,0.0004633308],"domain_scores_gemma":[0.9993145,0.000199212,0.0001072142,0.0002596047,0.00002295134,0.00009649522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004212154,0.0004728648,0.002001075,0.00004631907,5.764189e-7,0.00005152422,0.00009464529,0.00005402768,0.946793,0.02923568,0.002242755,0.01896544],"study_design_scores_gemma":[0.001701555,0.002549784,0.009169652,0.000072218,0.000004260968,0.000346387,0.00001455394,0.01228486,0.9319504,0.009787135,0.03163889,0.0004802843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964987,0.0002948439,0.00005642868,0.001038837,0.001609279,0.0002580967,0.00000233714,0.000042635,0.0001988356],"genre_scores_gemma":[0.9945687,0.004713185,0.00003147424,0.0004718977,0.00006122838,0.00003592567,4.747091e-7,0.00001452302,0.0001025686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02939614,"threshold_uncertainty_score":0.5307813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1530959227660363,"score_gpt":0.3823982107699627,"score_spread":0.2293022880039264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}