{"id":"W1997062198","doi":"10.1038/leu.2012.331","title":"CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing","year":2012,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Homing (biology); Bone marrow; Haematopoiesis; Neutrophilia; breakpoint cluster region; Leukemia; Biology; Cancer research; Spleen; Immunology; ABL; Transplantation; Myeloid; Myeloid leukemia; Chronic myelogenous leukemia; Stem cell; Medicine; Internal medicine; Signal transduction; Cell biology; Receptor; Genetics; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002528736,0.0004029008,0.0003290711,0.0006898002,0.0005483812,0.000913579,0.0008793423,0.0004367089,0.004073162],"category_scores_gemma":[0.0003804327,0.0003054042,0.0002616045,0.0002290313,0.0006025198,0.0003450679,0.0006170963,0.001395165,0.001371638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001081246,"about_ca_system_score_gemma":0.0004982692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001627499,"about_ca_topic_score_gemma":0.002608166,"domain_scores_codex":[0.9995033,0.00006225588,0.00004172633,0.00009222829,0.000159403,0.0001410935],"domain_scores_gemma":[0.9995953,0.00004823536,0.0001390506,0.00004517187,0.00003762489,0.0001344907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001834048,0.00002585932,0.0002241036,0.00001876375,0.000004411669,0.00009669409,0.000008440394,0.00003257417,0.9979206,0.0003260349,0.0001673069,0.0009919091],"study_design_scores_gemma":[0.00006904741,0.00007047804,0.01091421,0.0000103992,0.00001942715,0.0008180318,0.00004948739,0.001101325,0.9815321,0.0002281742,0.005175823,0.00001159249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824524,0.004241303,0.004332003,0.0006313561,0.0001163696,0.00003960716,0.001261298,0.0004922625,0.006433341],"genre_scores_gemma":[0.9942848,0.0002685864,0.001337628,0.0001073037,0.0000134253,0.00002818247,0.0009049388,0.00007920659,0.002976018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004073162,"threshold_uncertainty_score":0.0136261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02654607760618567,"score_gpt":0.2824213171881071,"score_spread":0.2558752395819214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}