{"id":"W1997062198","doi":"10.1038/leu.2012.331","title":"CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing","year":2012,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Homing (biology); Bone marrow; Haematopoiesis; Neutrophilia; breakpoint cluster region; Leukemia; Biology; Cancer research; Spleen; Immunology; ABL; Transplantation; Myeloid; Myeloid leukemia; Chronic myelogenous leukemia; Stem cell; Medicine; Internal medicine; Signal transduction; Cell biology; Receptor; Genetics; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000349415,0.0003755574,0.000787742,0.0001202212,0.0001269879,0.00001223911,0.0001223811,0.0003410866,0.0004228946],"category_scores_gemma":[0.0005170412,0.0003462013,0.0002618712,0.0004134513,0.0001594657,0.0004615789,0.00006382349,0.0001612897,0.00008880048],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004300895,"about_ca_system_score_gemma":0.0007403414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005615196,"about_ca_topic_score_gemma":0.00001229784,"domain_scores_codex":[0.9975113,0.00007163531,0.0007336951,0.0004546138,0.0005157877,0.0007129696],"domain_scores_gemma":[0.9979327,0.0004871495,0.0004772032,0.0006464393,0.0002160454,0.0002404221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002133434,0.0004724404,0.02601147,0.0009898606,0.001175383,0.00001312538,0.008510973,0.00002935728,0.787225,0.0004666936,0.1559427,0.01702956],"study_design_scores_gemma":[0.01697806,0.0005008068,0.02445244,0.0004300669,0.0008922185,0.00007446646,0.0005437754,0.002145813,0.9185534,0.0006280852,0.03423974,0.0005611723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895882,0.002943029,0.001767953,0.0006759645,0.0003631309,0.00154318,0.0002465829,0.0001492051,0.002722732],"genre_scores_gemma":[0.9766536,0.000161739,0.01618459,0.0007073773,0.0004062215,0.0001797101,0.0006185315,0.0001037044,0.004984538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1313283,"threshold_uncertainty_score":0.999899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02654607760618567,"score_gpt":0.2824213171881071,"score_spread":0.2558752395819214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}