{"id":"W1997065147","doi":"10.2174/157016308783769432","title":"Targeting Apoptosis to Treat Multiple Sclerosis","year":2008,"lang":"en","type":"review","venue":"Current Drug Discovery Technologies","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"XIAP; Multiple sclerosis; Inhibitor of apoptosis; Immune system; Apoptosis; Gene knockdown; Cancer research; Disease; Immunology; Pathological; Medicine; Myelin; Biology; Programmed cell death; Pathology; Central nervous system; Neuroscience; Caspase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003642765,0.001020466,0.001277,0.002129066,0.0003050326,0.0006989231,0.0008762969,0.001059045,0.003172322],"category_scores_gemma":[0.0002247459,0.0002459377,0.0003350571,0.001391557,0.0005126582,0.0008894662,0.0006314832,0.001675484,0.004682492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007742119,"about_ca_system_score_gemma":0.0004327463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006597778,"about_ca_topic_score_gemma":0.001158408,"domain_scores_codex":[0.9998616,0.00001635888,0.00001133144,0.00002542264,0.00007034447,0.00001498229],"domain_scores_gemma":[0.9999199,0.00002097521,0.00001527259,0.0000051906,0.00002622489,0.00001246386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009001617,0.000144043,0.000123826,0.004828308,0.00007400991,0.0003924318,0.00005625654,0.0005607948,0.01262534,0.005859221,0.03082813,0.9444175],"study_design_scores_gemma":[0.00008303784,0.000170673,0.0005938886,0.0007826369,0.00005328113,0.002077515,0.0000312009,0.0002123222,0.004478808,0.003103387,0.9883944,0.00001883238],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005817235,0.9940128,0.0009404958,0.0003646691,0.0003778017,0.00002039891,0.00002878212,0.00005225037,0.003621179],"genre_scores_gemma":[0.002709711,0.9913915,0.0009790796,0.0004123846,0.0001869005,0.00003849704,0.00007287433,0.000006762529,0.004202134],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003172322,"threshold_uncertainty_score":0.01061243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04851015421072599,"score_gpt":0.2896048743243783,"score_spread":0.2410947201136523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}