{"id":"W1997065147","doi":"10.2174/157016308783769432","title":"Targeting Apoptosis to Treat Multiple Sclerosis","year":2008,"lang":"en","type":"review","venue":"Current Drug Discovery Technologies","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"XIAP; Multiple sclerosis; Inhibitor of apoptosis; Immune system; Apoptosis; Gene knockdown; Cancer research; Disease; Immunology; Pathological; Medicine; Myelin; Biology; Programmed cell death; Pathology; Central nervous system; Neuroscience; Caspase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008131607,0.0006297321,0.0009210141,0.000279638,0.0002098953,0.00009347769,0.0006590287,0.0005366726,0.000003622898],"category_scores_gemma":[0.0002333119,0.0004896394,0.000599112,0.0003759404,0.0001226273,0.00001403681,0.0007941925,0.000294075,0.00004781491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008010508,"about_ca_system_score_gemma":0.0001130663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007077439,"about_ca_topic_score_gemma":0.000002668767,"domain_scores_codex":[0.9977908,0.00005769098,0.0005274221,0.0009410424,0.0002084158,0.0004746157],"domain_scores_gemma":[0.9987678,0.00003196074,0.0002778115,0.0008125153,0.0000518739,0.00005803837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000067859,0.00007916495,0.000008099133,0.001525737,0.0000457487,7.993967e-7,0.00001112147,0.00002516884,0.00164586,0.0000465256,0.01500439,0.9816006],"study_design_scores_gemma":[0.0001420799,0.00006003537,0.000001072309,0.00264044,0.0001305186,0.000006874271,0.00008448166,0.000005158157,0.008860449,0.00003075215,0.9874046,0.0006335259],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000778781,0.9954506,0.001534966,0.00003383576,0.000767034,0.0009214928,0.0001825783,0.000272647,0.000058062],"genre_scores_gemma":[0.001072606,0.9959056,0.0004856814,0.000006791987,0.0002137305,0.0003846972,0.001289581,0.00008302894,0.0005582665],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9809671,"threshold_uncertainty_score":0.9997555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04851015421072599,"score_gpt":0.2896048743243783,"score_spread":0.2410947201136523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}