{"id":"W1997076510","doi":"10.1074/jbc.m700601200","title":"Ubiquinone-binding Site Mutations in the Saccharomyces cerevisiae Succinate Dehydrogenase Generate Superoxide and Lead to the Accumulation of Succinate","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Fondation pour la Recherche Médicale","keywords":"Succinate dehydrogenase; Citric acid cycle; Biochemistry; Biology; Aconitase; SDHD; Respiratory chain; Mutant; Fumarase; Mitochondrion; Chemistry; Enzyme; Mutation; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001206251,0.000141767,0.0002253563,0.00003931412,0.00008077753,0.00002713692,0.0002592515,0.0001550384,0.00001508231],"category_scores_gemma":[0.0002437648,0.00007857967,0.0001187895,0.0001778229,0.00007815607,0.000009807551,0.00006805883,0.000202988,0.000001304429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001889155,"about_ca_system_score_gemma":0.00004243188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001645756,"about_ca_topic_score_gemma":0.00003904496,"domain_scores_codex":[0.9988847,0.00007919093,0.0004813984,0.0001813284,0.0001469534,0.0002263634],"domain_scores_gemma":[0.9992676,0.0000845298,0.0002603482,0.0001775635,0.0001288812,0.00008109025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001515885,0.00004039627,0.005057119,0.00001794368,0.00002507887,0.00000724162,0.0001637257,0.0001596363,0.9919003,0.000006418333,0.0001776341,0.002292901],"study_design_scores_gemma":[0.0005661292,0.0001476699,0.0245986,0.00002816013,0.00003194151,0.0001899747,0.000412833,0.00002110898,0.9605522,0.00003753382,0.01329011,0.000123807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944347,0.004416088,0.0002766291,0.0005194577,0.0001060678,0.0001213567,0.00002476634,0.000002235377,0.00009873931],"genre_scores_gemma":[0.9974478,0.001202432,0.0002838589,0.0002302373,0.0007436366,0.000003560669,0.00003129091,0.000007209057,0.00004992623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03134818,"threshold_uncertainty_score":0.3204386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03800423382870676,"score_gpt":0.3117684301951629,"score_spread":0.2737641963664562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}