{"id":"W1997121017","doi":"10.1006/viro.2001.1032","title":"Mutations at Amino Acid Positions 63, 189, and 396 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Partially Restore the DNA Polymerase Activity of a TRP229TYR Mutant RT","year":2001,"lang":"en","type":"article","venue":"Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds Wetenschappelijk Onderzoek; European Commission","keywords":"Reverse transcriptase; Biology; Mutant; Primer (cosmetics); Polymerase; DNA polymerase; Molecular biology; Mutation; Recombinant DNA; Resistance mutation; Virus; Point mutation; Enzyme; Virology; DNA; RNA; Biochemistry; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851115,0.0007144045,0.0004634121,0.0002387841,0.0003874178,0.0004143837,0.000384727,0.0005856574,0.00265207],"category_scores_gemma":[0.000436585,0.0002732552,0.0006052583,0.0001854956,0.0004151578,0.0002327294,0.0003094214,0.000788914,0.001975576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003300341,"about_ca_system_score_gemma":0.0003000803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163176,"about_ca_topic_score_gemma":0.0007359711,"domain_scores_codex":[0.9998228,0.00003287357,0.00002786077,0.00002415356,0.0000590635,0.00003322252],"domain_scores_gemma":[0.9996095,0.0001089689,0.0001109226,0.00004439904,0.00002156967,0.0001046629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003402017,0.0001068058,0.0004495514,0.00004055067,0.00002467263,0.00102851,0.00006110299,0.0005251649,0.9941044,0.0003809552,0.0001583031,0.002779734],"study_design_scores_gemma":[0.00009833862,0.0005546918,0.003096833,0.00002170549,0.00005139049,0.003838994,0.0000749046,0.003081364,0.984536,0.0002657236,0.004349209,0.00003088784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941554,0.0004367538,0.00305036,0.0001043198,0.0001033829,0.00003325135,0.0003212724,0.0001959762,0.001599248],"genre_scores_gemma":[0.9951037,0.0002506339,0.001832268,0.0000590376,0.00003302727,0.00002061992,0.0005347775,0.000104762,0.002061281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00265207,"threshold_uncertainty_score":0.008872092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174328661316412,"score_gpt":0.2783521067979468,"score_spread":0.2566088201847827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}