{"id":"W1997121017","doi":"10.1006/viro.2001.1032","title":"Mutations at Amino Acid Positions 63, 189, and 396 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Partially Restore the DNA Polymerase Activity of a TRP229TYR Mutant RT","year":2001,"lang":"en","type":"article","venue":"Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds Wetenschappelijk Onderzoek; European Commission","keywords":"Reverse transcriptase; Biology; Mutant; Primer (cosmetics); Polymerase; DNA polymerase; Molecular biology; Mutation; Recombinant DNA; Resistance mutation; Virus; Point mutation; Enzyme; Virology; DNA; RNA; Biochemistry; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464549,0.0001639034,0.0003541515,0.0001380142,0.0002476541,0.000003962138,0.00008122938,0.0001025912,0.0003138488],"category_scores_gemma":[0.00003759179,0.0001199535,0.00009042302,0.0002637946,0.0004230968,0.00005764879,0.00003443148,0.0001276847,0.00001966272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006205244,"about_ca_system_score_gemma":0.000118212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002495148,"about_ca_topic_score_gemma":0.0004239951,"domain_scores_codex":[0.9989074,0.0001289043,0.0003217001,0.0002382299,0.0001632606,0.000240486],"domain_scores_gemma":[0.9993145,0.00007215179,0.000135979,0.0003312348,0.00006582554,0.0000802353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007581949,0.0007619258,0.006174238,0.00002105034,0.0001667781,0.0001758768,0.002420607,0.000001877793,0.9880253,0.0003870499,0.0002242326,0.0008828653],"study_design_scores_gemma":[0.005966961,0.00225593,0.3551832,0.00007700455,0.001315998,0.0007612759,0.0004956718,0.00009709393,0.6296808,0.0002746164,0.003585174,0.0003062765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950224,0.000720383,0.00004387362,0.002986111,0.00007426518,0.0003704988,0.00008738756,0.00002376511,0.0006712988],"genre_scores_gemma":[0.9980391,0.0001900218,0.00009694577,0.000175576,0.00001922321,0.00003143539,0.00008792058,0.00001504516,0.001344698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3583445,"threshold_uncertainty_score":0.489156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174328661316412,"score_gpt":0.2783521067979468,"score_spread":0.2566088201847827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}