{"id":"W1997135231","doi":"10.1016/j.cellimm.2012.12.001","title":"The TLR2 agonists lipoteichoic acid and Pam3CSK4 induce greater pro-inflammatory responses than inactivated Mycobacterium butyricum","year":2012,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lipoteichoic acid; TLR2; Biology; Innate immune system; Immune system; Microbiology; Toll-like receptor; Antigen presentation; Receptor; TLR4; Immunology; T cell; Bacteria; Staphylococcus aureus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001077754,0.00042916,0.0004382056,0.0002271861,0.0009918587,0.00007817646,0.0004289649,0.000768627,0.0001707066],"category_scores_gemma":[0.0003516877,0.0003124661,0.0001266288,0.0002090407,0.0008631524,0.0004531287,0.0003521217,0.0007778981,0.001176081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001188856,"about_ca_system_score_gemma":0.0001567291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004777524,"about_ca_topic_score_gemma":0.000006504701,"domain_scores_codex":[0.9962661,0.001547594,0.000599711,0.0003971692,0.00006600466,0.001123375],"domain_scores_gemma":[0.9982776,0.0004024483,0.000329285,0.0008254457,0.000114877,0.00005035142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001814977,0.00006355453,0.006956622,0.00001914243,0.0004048948,0.00001222248,0.001222652,6.014052e-8,0.9827151,0.0012357,0.0003092783,0.005245822],"study_design_scores_gemma":[0.0009021279,0.000199504,0.09573476,0.00002603098,0.00005653451,0.0003228755,0.0004049598,7.156195e-7,0.7618131,0.00006332984,0.1401687,0.0003073005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652782,0.03031049,0.00004476393,0.0008959715,0.002287825,0.0005024791,0.000007304251,0.0001726145,0.0005003504],"genre_scores_gemma":[0.9908747,0.0008113416,0.00001771135,0.00008490551,0.0001438929,0.0001038513,0.0001271732,0.00005274851,0.007783676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.220902,"threshold_uncertainty_score":0.9999328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198521385750123,"score_gpt":0.2171993990563619,"score_spread":0.2052141851988607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}