{"id":"W1997140139","doi":"10.1089/omi.2009.0011","title":"Risk Assessment and Communication Tools for Genotype Associations with Multifactorial Phenotypes: The Concept of “Edge Effect” and Cultivating an Ethical Bridge between Omics Innovations and Society","year":2009,"lang":"en","type":"article","venue":"OMICS A Journal of Integrative Biology","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Pharmacogenomics; Omics; Population; Biology; Personalized medicine; Genetic association; Precision medicine; Data science; Biotechnology; Bioinformatics; Genetics; Medicine; Single-nucleotide polymorphism; Genotype; Computer science; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1131623,0.002212462,0.002006731,0.009615254,0.002218489,0.009014864,0.003319551,0.005201097,0.006508526],"category_scores_gemma":[0.2653188,0.001202699,0.002572679,0.003748347,0.01715722,0.01563832,0.0106443,0.008580243,0.001430305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002653681,"about_ca_system_score_gemma":0.003429723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001108286,"about_ca_topic_score_gemma":0.0006922966,"domain_scores_codex":[0.8845062,0.0895066,0.004719633,0.00547849,0.01496681,0.0008223226],"domain_scores_gemma":[0.4943369,0.4525166,0.01891464,0.02085343,0.01166526,0.001713293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004488946,0.0001601866,0.02133884,0.001370546,0.0005851361,0.0007121674,0.007444701,0.00627582,0.001219191,0.6230172,0.01061227,0.326815],"study_design_scores_gemma":[0.0001064956,0.0003416419,0.0058891,0.001776163,0.0003513115,0.001603041,0.001975732,0.01774623,0.001564848,0.9160804,0.05229561,0.000269432],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.01132279,0.004890445,0.9346806,0.03438191,0.0008413336,0.0002346741,0.0004469256,0.0005004077,0.01270089],"genre_scores_gemma":[0.3553357,0.004579787,0.6215877,0.01094234,0.00294361,0.001096475,0.0003831857,0.0003717443,0.002759556],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1131623,"threshold_uncertainty_score":0.5984668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234675879850919,"score_gpt":0.3458051585407783,"score_spread":0.3234583997422691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}