{"id":"W1997185511","doi":"10.1016/s0047-6374(03)00124-6","title":"Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle","year":2003,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Genentech","keywords":"P70-S6 Kinase 1; Protein kinase B; Endocrinology; Internal medicine; Phosphorylation; Skeletal muscle; Basal (medicine); Biology; Chemistry; Insulin; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003296762,0.0005736448,0.0003072517,0.001155647,0.0001857231,0.0003635733,0.0002591553,0.0004883026,0.002324837],"category_scores_gemma":[0.0001998169,0.0005977784,0.0005611636,0.0003525611,0.0003268939,0.0007687291,0.0003259115,0.0007792473,0.0004891423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005338902,"about_ca_system_score_gemma":0.0001686862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009551885,"about_ca_topic_score_gemma":0.001756461,"domain_scores_codex":[0.9997782,0.00002247664,0.0000340402,0.00006101783,0.00004362262,0.00006062838],"domain_scores_gemma":[0.9997018,0.00002825548,0.0001182438,0.00003873169,0.00003493355,0.00007799565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000473887,0.00002740978,0.0004716571,0.00002307136,0.000008239647,0.00004510472,0.0000183842,0.00003139174,0.9979132,0.0001449665,0.00003246083,0.0008101969],"study_design_scores_gemma":[0.00003537348,0.0004961491,0.05394617,0.00001003022,0.00005503847,0.0002964094,0.00007138426,0.0003696104,0.9425359,0.0002215133,0.001949127,0.00001328052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903747,0.003546896,0.00227415,0.0001449742,0.0000816987,0.00002793288,0.001492131,0.000124277,0.001933155],"genre_scores_gemma":[0.9820169,0.00213956,0.001539647,0.0001395972,0.00003893517,0.000118223,0.001399318,0.00006719059,0.01254063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324837,"threshold_uncertainty_score":0.007777393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533394980421839,"score_gpt":0.2239337056921576,"score_spread":0.2085997558879392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}