{"id":"W1997205733","doi":"10.1016/j.metabol.2003.09.011","title":"Insulin regulates hepatic apolipoprotein B production independent of the mass or activity of Akt1/PKBα","year":2004,"lang":"en","type":"article","venue":"Metabolism","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Apolipoprotein B; Protein kinase B; Transfection; AKT1; Internal medicine; Endocrinology; PI3K/AKT/mTOR pathway; Chemistry; Insulin; Phosphorylation; Molecular biology; Biology; Biochemistry; Signal transduction; Medicine; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421616,0.0005089928,0.0002237767,0.0004227446,0.0001554238,0.0006415689,0.0001675834,0.0001746286,0.00161747],"category_scores_gemma":[0.0001130138,0.0003676067,0.0002847027,0.0002566073,0.0003374566,0.0003567201,0.0002031492,0.0006044302,0.0005045338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003927411,"about_ca_system_score_gemma":0.0001564211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005833271,"about_ca_topic_score_gemma":0.0007437557,"domain_scores_codex":[0.9999151,0.00001437618,0.000008750501,0.00002549859,0.00001704497,0.00001925901],"domain_scores_gemma":[0.9998659,0.00001504015,0.00003129435,0.00002182068,0.00001466593,0.0000512213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003064464,0.00008381386,0.001301424,0.00005216578,0.00002483909,0.0001396752,0.00001860882,0.00004396898,0.9904181,0.000300922,0.00016866,0.004383406],"study_design_scores_gemma":[0.0003596961,0.0005906128,0.0423472,0.0000167136,0.0001306391,0.0004298369,0.0001057011,0.001247175,0.9498134,0.0004728264,0.004466399,0.00001971789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861428,0.003724859,0.004013452,0.0002911583,0.000192619,0.00002236201,0.0004542005,0.0003527576,0.004805705],"genre_scores_gemma":[0.9910382,0.001699995,0.002294727,0.000125353,0.0000477451,0.0000243967,0.0003390334,0.00007176075,0.004358761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00161747,"threshold_uncertainty_score":0.005410969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163376379477465,"score_gpt":0.2443872906972933,"score_spread":0.2327535269025187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}