{"id":"W1997209262","doi":"10.1016/j.stem.2011.06.002","title":"Cell Fate Potential of Human Pluripotent Stem Cells Is Encoded by Histone Modifications","year":2011,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Embryonic stem cell; Induced pluripotent stem cell; Cell fate determination; Cell biology; Cellular differentiation; Lineage (genetic); Histone; Stem cell; Cell type; Cell; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279997,0.0001490754,0.00007723222,0.0001495881,0.0001268973,0.0003290937,0.0001180382,0.0001461619,0.001682714],"category_scores_gemma":[0.0002203411,0.0001253437,0.0001155103,0.0001608185,0.0001733814,0.0002172828,0.0001950652,0.0002673729,0.0005691213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001574321,"about_ca_system_score_gemma":0.0001040769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001797424,"about_ca_topic_score_gemma":0.0003226613,"domain_scores_codex":[0.9999347,0.00001052949,0.000004890785,0.00001700024,0.0000207234,0.00001216529],"domain_scores_gemma":[0.9998778,0.00003773299,0.00002703765,0.00001649217,0.00002023299,0.00002063667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009278818,0.000003718656,0.0005766041,0.00001669866,0.000004232735,0.00004325768,0.00002317142,0.00005389192,0.9959469,0.0005951907,0.00004194862,0.00260152],"study_design_scores_gemma":[0.00001069127,0.00006546206,0.009909394,0.000005841295,0.00001783469,0.0002357058,0.00004003971,0.0003949157,0.9856614,0.0006191995,0.003033532,0.000005894985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865947,0.001785752,0.006038493,0.0001970719,0.00004557112,0.00001027565,0.0006537714,0.0000531902,0.004621232],"genre_scores_gemma":[0.9956591,0.0005757889,0.0008009459,0.00005096567,0.000009422174,0.000005043499,0.0004981206,0.00001906731,0.002381527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001682714,"threshold_uncertainty_score":0.005629301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.023775753588172,"score_gpt":0.2494639512155521,"score_spread":0.2256881976273801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}