{"id":"W1997223441","doi":"10.1016/j.stem.2008.03.012","title":"Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3","year":2008,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Biology; Stem cell; Cell biology; Haematopoiesis; MAPK/ERK pathway; Progenitor cell; Hematopoietic stem cell; Caspase; Cell; Population; Signal transduction; Immunology; Apoptosis; Programmed cell death; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003811707,0.0003647561,0.0003524655,0.0004128174,0.000233263,0.001242277,0.0003215595,0.0004128575,0.004403827],"category_scores_gemma":[0.000458136,0.0002117769,0.0003940386,0.0002457809,0.0004507732,0.0005316293,0.0004201809,0.00191834,0.001014333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000484683,"about_ca_system_score_gemma":0.0004022465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002136234,"about_ca_topic_score_gemma":0.0003838234,"domain_scores_codex":[0.9994541,0.0001150221,0.00007114181,0.0001057496,0.0001283092,0.0001257526],"domain_scores_gemma":[0.999408,0.0001965762,0.0001417838,0.0001079178,0.00004423989,0.0001015178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002378644,0.00003867385,0.0002244203,0.00002747594,0.000007784098,0.00004481931,0.00001743876,0.00005242357,0.9976856,0.0003592868,0.00009301987,0.001211268],"study_design_scores_gemma":[0.00003786095,0.0001235147,0.002626925,0.000008548765,0.0000125364,0.0002508314,0.0000409726,0.0008551444,0.9935179,0.0001727691,0.00234871,0.000004267904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813588,0.003421951,0.006727174,0.0006174495,0.0001471124,0.00006097841,0.0009440875,0.0002438292,0.00647846],"genre_scores_gemma":[0.9946714,0.0004661559,0.001886755,0.0001198156,0.00001823835,0.00003126304,0.0006573827,0.00003775447,0.002111184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004403827,"threshold_uncertainty_score":0.0147323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850291733594961,"score_gpt":0.2457195135636067,"score_spread":0.2172165962276571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}