{"id":"W1997226402","doi":"10.1371/journal.pone.0077097","title":"A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic ß-Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Isocitrate dehydrogenase; Biology; Malic enzyme; NAD+ kinase; Biochemistry; Citric acid cycle; Cytosol; Lipogenesis; IDH1; Metabolism; Enzyme; Dehydrogenase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001489185,0.0004043761,0.0002970959,0.000177867,0.0001533328,0.0007270918,0.0002950339,0.0003138836,0.001147958],"category_scores_gemma":[0.0001353991,0.0001203782,0.0003255097,0.000174825,0.0002944542,0.0003588962,0.0003184127,0.0007073851,0.0004310694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000365042,"about_ca_system_score_gemma":0.0002615365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004352846,"about_ca_topic_score_gemma":0.0005024284,"domain_scores_codex":[0.9998685,0.000013451,0.00001011328,0.00004447327,0.000037269,0.00002607706],"domain_scores_gemma":[0.9998392,0.00001151398,0.00004127004,0.00001655005,0.0000437779,0.00004769276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760691,0.00003306922,0.001266296,0.0001692531,0.00002039888,0.0002904464,0.00002909556,0.00009548823,0.9910163,0.001101937,0.000336918,0.005364703],"study_design_scores_gemma":[0.0001210392,0.000632711,0.05931322,0.0001118193,0.0001437416,0.001505749,0.0002720774,0.004218476,0.8957576,0.001460917,0.03641962,0.00004300654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9106445,0.04581749,0.02670337,0.002533862,0.0009969389,0.00007543223,0.0009505933,0.0005869967,0.01169079],"genre_scores_gemma":[0.9776117,0.01090883,0.003698249,0.0005856161,0.000109679,0.00003530538,0.0008672129,0.00004111173,0.006142404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001147958,"threshold_uncertainty_score":0.003840268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02508486594739585,"score_gpt":0.234435416817844,"score_spread":0.2093505508704482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}