{"id":"W1997256437","doi":"10.1021/ac8020449","title":"Structural Characterization of an Integral Membrane Protein in Its Natural Lipid Environment by Oxidative Methionine Labeling and Mass Spectrometry","year":2008,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Lipid bilayer; Oxidative phosphorylation; Membrane protein; Tandem mass spectrometry; Mass spectrometry; Membrane; Protein structure; Chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139356,0.0001398078,0.0002079848,0.00005403171,0.00005485766,0.00001808933,0.0001850288,0.00009016392,0.0003029646],"category_scores_gemma":[0.000295916,0.0001237163,0.00003236713,0.0002601691,0.0002289687,0.000140062,0.00007142048,0.0003717449,0.000003040666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006634864,"about_ca_system_score_gemma":0.00002693893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005606378,"about_ca_topic_score_gemma":2.595489e-7,"domain_scores_codex":[0.998679,0.00006526512,0.0002404521,0.0003732152,0.0003838827,0.0002582262],"domain_scores_gemma":[0.9995727,0.00006065958,0.00006185081,0.0001481779,0.00002408793,0.0001325067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006022743,0.0000440498,0.0005597384,0.00003983124,0.000004800354,0.00001005356,0.0000591808,0.000003094756,0.9991232,0.00001610661,9.674343e-7,0.00007878003],"study_design_scores_gemma":[0.0003296248,0.0000514508,0.001150433,0.00001546327,0.000004433499,0.00001292183,0.00001662904,0.02221496,0.9760384,0.00002139074,0.00001982431,0.0001244977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994351,0.00003472612,0.00002720038,0.00007556481,0.00001295996,0.0001410796,0.00004412626,0.00001036763,0.0002189374],"genre_scores_gemma":[0.9989058,0.0001061897,0.0003353889,0.00002338674,0.00004012035,0.000007844258,0.00005329735,0.00001155815,0.0005164195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0230848,"threshold_uncertainty_score":0.5045004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244358100843882,"score_gpt":0.2773084985713382,"score_spread":0.25287268848695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}