{"id":"W1997278932","doi":"10.1039/c0ob00093k","title":"Synthesis and characterization of an O6-2′-deoxyguanosine-alkyl-O6-2′-deoxyguanosine interstrand cross-link in a 5′-GNC motif and repair by human O6-alkylguanine-DNA alkyltransferase","year":2010,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Cancer Institute; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Chemistry; Deoxyguanosine; DNA; Duplex (building); Guanine; Stereochemistry; Nucleotide; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149672,0.0001468792,0.0001253962,0.0001135885,0.00006957901,0.0001274653,0.00009435009,0.0001931275,0.0005235019],"category_scores_gemma":[0.0002038123,0.00009104343,0.0001134339,0.0001234465,0.00008411515,0.00008592712,0.00006644762,0.0001761828,0.0003081532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001184571,"about_ca_system_score_gemma":0.0001505663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000353519,"about_ca_topic_score_gemma":0.0006188077,"domain_scores_codex":[0.9999379,0.000008904063,0.000005156339,0.0000197647,0.00002193718,0.000006398774],"domain_scores_gemma":[0.9998374,0.00002498366,0.00004287286,0.0000190469,0.00003953884,0.0000360468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008835263,0.000007285072,0.00006329214,0.00001266355,0.00000134672,0.00001210134,0.000006250888,0.00005948202,0.9991431,0.0000225594,0.000005864934,0.000657294],"study_design_scores_gemma":[0.000002541098,0.0002270472,0.001296571,0.000001688647,0.00000591323,0.00008959791,0.000008383509,0.0002637458,0.9958197,0.0000120698,0.00227066,0.000002153318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844574,0.0007241267,0.01324683,0.00003263418,0.00001250505,0.00007496773,0.0004413462,0.0000638459,0.0009462748],"genre_scores_gemma":[0.9660547,0.0006285275,0.02516797,0.0000540781,0.00000654122,0.00007830708,0.002254312,0.00004343607,0.00571202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005235019,"threshold_uncertainty_score":0.001751304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003418606436699425,"score_gpt":0.2242356336309993,"score_spread":0.2208170271942999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}