{"id":"W1997283150","doi":"10.1038/embor.2012.17","title":"TCR‐mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells","year":2012,"lang":"en","type":"article","venue":"EMBO Reports","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Medizinischen Hochschule Hannover; Deutsche Forschungsgemeinschaft; Cochlear","keywords":"T-cell receptor; MAPK/ERK pathway; GRB2; Cell biology; Activator (genetics); Biology; T cell; Guanine nucleotide exchange factor; Signal transduction; Receptor; Genetics; Signal transducing adaptor protein; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003162167,0.0002107212,0.0003007625,0.0001339989,0.0001766116,0.00001450942,0.00007239058,0.0003743765,0.0008027701],"category_scores_gemma":[0.00005309873,0.0001598195,0.00005082797,0.00008332638,0.0001343916,0.0001660099,0.00007110416,0.0003975848,0.0001201204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005585026,"about_ca_system_score_gemma":0.00002664043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003209832,"about_ca_topic_score_gemma":0.0001099892,"domain_scores_codex":[0.9985444,0.0001567396,0.0004287463,0.0003425299,0.00004235072,0.0004852094],"domain_scores_gemma":[0.9992986,0.00009595788,0.000233047,0.0003114091,0.0000277794,0.00003326297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006722967,0.0002645011,0.02764349,0.00001073586,0.00004793801,0.00005696671,0.0006777425,0.00000174091,0.9696202,0.000118992,0.0006551553,0.0008353085],"study_design_scores_gemma":[0.0007332336,0.000136852,0.03449161,0.00002811404,0.00001582619,0.0002161427,0.0001626354,5.970802e-7,0.943565,0.0001361563,0.02028334,0.0002305117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954669,0.0004445253,0.000005404317,0.0001529301,0.001434318,0.0002418017,0.000004856736,0.00007094188,0.002178336],"genre_scores_gemma":[0.9944142,0.00003843195,0.00001918467,0.000245915,0.0000804219,0.00002766479,0.0001311946,0.00002145291,0.005021569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02605522,"threshold_uncertainty_score":0.878977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267152784186398,"score_gpt":0.2360891947847769,"score_spread":0.2234176669429129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}