{"id":"W1997300266","doi":"10.1016/j.chembiol.2009.10.012","title":"A Genetic Screen for Isolating “Lariat” Peptide Inhibitors of Protein Function","year":2009,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Repressor lexA; Biology; Intein; Mutant; Repressor; Peptide; Function (biology); SOS response; Biochemistry; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002662079,0.0008748486,0.0007034336,0.0005510393,0.0002287074,0.0004855738,0.000562161,0.0004300599,0.001337651],"category_scores_gemma":[0.0003007416,0.0002792988,0.0004670285,0.0003693899,0.0003236493,0.0001999853,0.0003091387,0.000795819,0.0005430606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004383823,"about_ca_system_score_gemma":0.0003501798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008414324,"about_ca_topic_score_gemma":0.00135258,"domain_scores_codex":[0.9997604,0.00003232402,0.00002301021,0.00004058982,0.00009637338,0.00004719062],"domain_scores_gemma":[0.9998167,0.00005746294,0.00005235425,0.00001535135,0.00002693301,0.00003125607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007770266,0.00006141237,0.0001332192,0.00003327934,0.00001509432,0.0001382762,0.000007406993,0.0002280171,0.9973349,0.0001038862,0.00007285559,0.001793785],"study_design_scores_gemma":[0.00002918344,0.0003212005,0.0004477331,0.00000370611,0.00004148353,0.0003622503,0.00001138224,0.000836295,0.996064,0.00001672865,0.001861331,0.000004739413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651117,0.003282205,0.02322987,0.0004043319,0.0001198564,0.0003662195,0.001401087,0.0007885747,0.005296102],"genre_scores_gemma":[0.9731472,0.002071248,0.01677506,0.0002290057,0.0000308782,0.0001127303,0.002259747,0.0001271651,0.005246976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337651,"threshold_uncertainty_score":0.004474878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064679215098568,"score_gpt":0.2403609601198798,"score_spread":0.2297141679688942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}