{"id":"W1997300266","doi":"10.1016/j.chembiol.2009.10.012","title":"A Genetic Screen for Isolating “Lariat” Peptide Inhibitors of Protein Function","year":2009,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Repressor lexA; Biology; Intein; Mutant; Repressor; Peptide; Function (biology); SOS response; Biochemistry; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009513101,0.0001009155,0.000215316,0.00001741141,0.00003520929,0.00000297406,0.00005000354,0.000180483,0.00008810484],"category_scores_gemma":[0.0002629096,0.00007677731,0.00008458109,0.00007373335,0.00005096201,0.00001262743,0.00001394018,0.0001009035,0.000002147635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001927101,"about_ca_system_score_gemma":0.00003770783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000139668,"about_ca_topic_score_gemma":5.554986e-7,"domain_scores_codex":[0.9993333,0.000008867934,0.0002285976,0.0002306782,0.00003320351,0.0001653409],"domain_scores_gemma":[0.9995672,0.00001814697,0.0001144502,0.0001587494,0.00009846965,0.0000430255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002513233,0.00004545059,0.0003268042,0.0001115098,0.00002139996,5.547816e-7,0.000008293084,2.035948e-7,0.9798948,0.00001489649,0.0004141387,0.01891068],"study_design_scores_gemma":[0.0004824642,0.0004044877,0.001678561,0.00007991026,0.00005478157,0.0000146473,0.0000145984,0.00002728215,0.9922258,0.0003036481,0.004628782,0.00008501541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996811,0.0004885982,0.0003216679,0.001306789,0.00004109806,0.0003847625,0.00001703319,0.00002821613,0.0006007747],"genre_scores_gemma":[0.9943243,0.000005860955,0.004192175,0.0001513722,0.0006484069,0.000002206792,0.00005109327,0.000006726408,0.0006178594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01882567,"threshold_uncertainty_score":0.3130888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064679215098568,"score_gpt":0.2403609601198798,"score_spread":0.2297141679688942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}