{"id":"W1997350836","doi":"10.1074/jbc.m807914200","title":"Glutamate Acting on N-Methyl-d-aspartate Receptors Attenuates Insulin-like Growth Factor-1 Receptor Tyrosine Phosphorylation and Its Survival Signaling Properties in Rat Hippocampal Neurons","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Phosphorylation; Hippocampal formation; Tyrosine phosphorylation; Glutamate receptor; Receptor; Chemistry; Insulin receptor; Insulin-like growth factor; Receptor tyrosine kinase; Endocrinology; Cell biology; Internal medicine; Insulin; Biology; Growth factor; Medicine; Biochemistry; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367185,0.0005193289,0.0005220215,0.0001873927,0.0001308706,0.0002096793,0.0002489459,0.0002350858,0.001207526],"category_scores_gemma":[0.0001334471,0.0001475636,0.0004510104,0.0002046813,0.0001994688,0.0002434229,0.0002011146,0.0007428161,0.0002582791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663557,"about_ca_system_score_gemma":0.0003899123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002043576,"about_ca_topic_score_gemma":0.004777462,"domain_scores_codex":[0.999873,0.00001263244,0.00002491635,0.00001978281,0.00002584686,0.00004377613],"domain_scores_gemma":[0.9999413,0.000005022908,0.0000174239,0.000007119228,0.000009146658,0.00001998033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008169225,0.0001285313,0.0003203806,0.0001559656,0.00002960975,0.00008698276,0.00003586442,0.00005840275,0.9959632,0.00005307083,0.00007008531,0.002280957],"study_design_scores_gemma":[0.0001362543,0.003190805,0.0163781,0.00003463646,0.0001104345,0.0002610489,0.0001559716,0.0006522842,0.9772091,0.00007947918,0.001777294,0.00001456702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941872,0.003888333,0.0005458758,0.0001160046,0.00008093027,0.00001814819,0.0002516586,0.00003370636,0.0008780881],"genre_scores_gemma":[0.9933162,0.003414584,0.0007156843,0.00008917241,0.00001797198,0.00005291283,0.0004578193,0.000006735778,0.001928915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002043576,"threshold_uncertainty_score":0.004063427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04283060005183177,"score_gpt":0.2413624131430223,"score_spread":0.1985318130911905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}