{"id":"W1997353298","doi":"10.1158/0008-5472.can-06-1593","title":"Impaired Dihydrotestosterone Catabolism in Human Prostate Cancer: Critical Role of AKR1C2 as a Pre-Receptor Regulator of Androgen Receptor Signaling","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Dihydrotestosterone; Androgen receptor; Androgen; Catabolism; Endocrinology; Internal medicine; Prostate cancer; Biology; Receptor; Prostate; Downregulation and upregulation; Cancer; Cancer research; Metabolism; Medicine; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002208487,0.0002649661,0.0007549416,0.0007715233,0.0001683055,0.00002603959,0.0003384256,0.0002269936,0.000997604],"category_scores_gemma":[0.0003995732,0.000231228,0.0001258803,0.00142969,0.001020464,0.000182013,0.0002146653,0.0007842579,0.00001648793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009133244,"about_ca_system_score_gemma":0.001955427,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009430806,"about_ca_topic_score_gemma":0.0004056443,"domain_scores_codex":[0.9954814,0.0002370044,0.0008123488,0.0006356281,0.001530605,0.001303026],"domain_scores_gemma":[0.997216,0.0003512672,0.0001270829,0.0005653425,0.001190749,0.0005494996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004714793,0.00055043,0.05955192,0.0009109773,0.0001308826,0.00004274087,0.003837017,0.00001718876,0.9199922,0.0002299116,0.0008301751,0.009191755],"study_design_scores_gemma":[0.004062789,0.00126832,0.01009689,0.001650359,0.00003946736,0.000006546466,0.001067715,0.00002920526,0.9778726,0.0004089019,0.003287258,0.0002100214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772167,0.01846442,0.000002422487,0.001504015,0.0001166705,0.001986366,0.0002463398,0.00003597914,0.0004270969],"genre_scores_gemma":[0.9950895,0.001565882,0.0001409269,0.0000292723,0.000322653,0.0005815065,0.00008277195,0.00007925435,0.00210826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05788031,"threshold_uncertainty_score":0.9999156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04372021552373926,"score_gpt":0.4234314886908429,"score_spread":0.3797112731671036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}