{"id":"W1997362085","doi":"10.1021/ja061216p","title":"Structural Basis of the Inhibition of Golgi α-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand−Protein Interactions","year":2006,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Chemistry; Stereochemistry; Moiety; Mannosidase; Ligand (biochemistry); Covalent bond; Mannose; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003239448,0.0001644855,0.0004417638,0.00001131311,0.0001279606,0.0000139063,0.0004888346,0.00007600363,0.00003025253],"category_scores_gemma":[0.0002729709,0.00007640258,0.0007663726,0.0004970769,0.001349883,0.00007028496,0.0002802521,0.000643513,4.638752e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114733,"about_ca_system_score_gemma":0.00006248289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005393298,"about_ca_topic_score_gemma":0.00001028078,"domain_scores_codex":[0.9984696,0.00009638348,0.0007236972,0.000131695,0.0004136937,0.0001649545],"domain_scores_gemma":[0.9974068,0.0003984592,0.001662012,0.0003621175,0.0001365754,0.00003403276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001420005,0.00009066397,0.002658056,0.00005809739,0.00008744428,1.493737e-7,0.0009893323,0.00003381837,0.994633,0.00002378668,0.0008476838,0.0004359254],"study_design_scores_gemma":[0.0006512551,0.00001008698,0.001367803,0.0002261817,0.00009876602,0.00001993336,0.002702992,0.0002227103,0.9929539,0.001526548,0.0001380798,0.000081771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964442,0.0002263223,0.000002048292,0.002657482,0.000025189,0.00008520442,0.0001010383,0.000002983616,0.0004555853],"genre_scores_gemma":[0.9995505,0.00002789998,0.0001007838,0.00009248543,0.00007793985,0.000005642478,0.000001796884,0.00001202681,0.0001309416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003106336,"threshold_uncertainty_score":0.4973699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003555386187653132,"score_gpt":0.2066726176263347,"score_spread":0.2031172314386816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}