{"id":"W1997363702","doi":"10.1016/j.neubiorev.2007.10.005","title":"Allostatic load in bipolar disorder: Implications for pathophysiology and treatment","year":2007,"lang":"en","type":"review","venue":"Neuroscience & Biobehavioral Reviews","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":482,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"GlaxoSmithKline; H. Lundbeck A/S; AstraZeneca; Pfizer","keywords":"Allostatic load; Allostasis; Dysfunctional family; Stressor; Mood; Psychology; Comorbidity; Clinical psychology; Bipolar disorder; Psychopathology; Psychological resilience; Psychiatry; Neuroscience; Psychotherapist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003393987,0.000617074,0.002248008,0.0002844807,0.0001407576,0.00003292478,0.0001867138,0.000242913,0.000009538016],"category_scores_gemma":[0.0001160346,0.0004007672,0.0005899888,0.0006516407,0.0002444905,0.00007478042,0.00006497493,0.0002290371,0.00002375164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003859401,"about_ca_system_score_gemma":0.0004493667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001232318,"about_ca_topic_score_gemma":0.0003326512,"domain_scores_codex":[0.9972503,0.0001055632,0.0009464692,0.0009783121,0.0001504827,0.0005688589],"domain_scores_gemma":[0.9986691,0.00001491501,0.0003334068,0.000682014,0.00004820184,0.0002523482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007117757,0.000736865,0.003303004,0.001902361,4.708398e-7,0.000006041128,0.00002690097,8.85509e-9,0.00005744825,0.00004382976,0.00002704145,0.9938889],"study_design_scores_gemma":[0.0006065394,0.001406676,0.00668155,0.001678034,0.001143055,0.00008439785,0.000003803689,0.000001266029,2.885678e-7,0.0000282489,0.9880822,0.0002838967],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001799851,0.9926353,0.00005962774,0.00002535127,0.0001487748,0.006706278,0.0001951707,0.0000316568,0.00001788053],"genre_scores_gemma":[0.00002550805,0.9965919,0.0005983987,0.0001879849,0.00003723713,0.00220948,0.000164457,0.00005099221,0.0001340937],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.993605,"threshold_uncertainty_score":0.9998444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1897916143922708,"score_gpt":0.4507513017508967,"score_spread":0.2609596873586258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}