{"id":"W1997391752","doi":"10.1097/qai.0b013e3181869a88","title":"Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-γ and Proliferation Responses","year":2008,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; University of Manitoba","keywords":"ELISPOT; Immunology; CD8; Biology; T cell; Immune system; Interferon; Epitope; Virology; Cytotoxic T cell; Interferon gamma; Lentivirus; HIV vaccine; Human immunodeficiency virus (HIV); Viral disease; Vaccine trial; Antibody; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006289126,0.0001807464,0.0001921186,0.000297001,0.0001178979,0.0002832988,0.0001324669,0.0002342604,0.00143235],"category_scores_gemma":[0.0008048893,0.0001241914,0.0001276739,0.0001241012,0.000203053,0.0001919337,0.0002312669,0.0004251536,0.0003329676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001068351,"about_ca_system_score_gemma":0.00008999237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001776677,"about_ca_topic_score_gemma":0.0002394082,"domain_scores_codex":[0.9997193,0.00008119315,0.00003017706,0.0000703817,0.00004809062,0.00005079983],"domain_scores_gemma":[0.9995667,0.0002441475,0.00004246837,0.00005989937,0.00004424662,0.00004253926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002886467,0.00006723354,0.01706189,0.00005889984,0.00001864917,0.0001121651,0.0001770935,0.0001031262,0.9661045,0.0001312564,0.00004863463,0.01582796],"study_design_scores_gemma":[0.00004932852,0.002717007,0.6199912,0.0000418934,0.00008754188,0.003539239,0.0004920206,0.001119879,0.3667532,0.0006712444,0.004516055,0.0000213806],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948431,0.0009264497,0.001615767,0.00003380995,0.00001170104,0.00003810596,0.0001304698,0.0000213081,0.002379217],"genre_scores_gemma":[0.9981154,0.0002113046,0.0007838223,0.00006388704,0.00001077826,0.00003598149,0.0001415342,0.000009968229,0.0006272295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143235,"threshold_uncertainty_score":0.004791737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03143048955022681,"score_gpt":0.2471974885083045,"score_spread":0.2157669989580777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}