{"id":"W1997427906","doi":"10.1016/j.cell.2013.09.002","title":"Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development","year":2013,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Biology; Transgenerational epigenetics; Epigenetics; Genetics; Mutation; Genome instability; Metabolism; Epigenesis; DNA methylation; Gene; DNA; DNA damage; Endocrinology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175737,0.00009828066,0.00008245384,0.00003994489,0.00004280343,0.00002119717,0.00003830776,0.00008092627,0.00001443234],"category_scores_gemma":[0.00002440469,0.00009320011,0.00001887426,0.0000438177,0.00001887735,0.000003814683,0.0000155773,0.00004254895,0.00001266273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001016322,"about_ca_system_score_gemma":0.00004233385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000196685,"about_ca_topic_score_gemma":0.0000708728,"domain_scores_codex":[0.9993438,0.00006513295,0.0001586772,0.0002322222,0.00007959585,0.0001206454],"domain_scores_gemma":[0.9997491,0.00002197934,0.00003153542,0.0001082841,0.00003968595,0.00004943763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009827813,0.00004977616,0.003413928,0.00002896949,0.000005860795,6.446718e-7,0.0001593666,0.0003500528,0.9814412,0.00001785304,0.000008477016,0.01451403],"study_design_scores_gemma":[0.0003637552,0.000076565,0.196626,0.000003977063,0.000003666256,1.999146e-7,0.000007369362,0.00009821877,0.8010285,0.0002958136,0.001403613,0.00009233147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960921,0.001934213,0.001231219,0.00003876551,0.00007675242,0.0002785,0.000001460456,0.000004067043,0.0003429421],"genre_scores_gemma":[0.9976935,0.0001417687,0.001792502,0.00007760058,0.00005386771,0.00006452239,0.00006566467,0.000009912429,0.0001006462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1932121,"threshold_uncertainty_score":0.380059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008165133723031619,"score_gpt":0.2234796840666694,"score_spread":0.2153145503436378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}