{"id":"W1997427906","doi":"10.1016/j.cell.2013.09.002","title":"Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development","year":2013,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Biology; Transgenerational epigenetics; Epigenetics; Genetics; Mutation; Genome instability; Metabolism; Epigenesis; DNA methylation; Gene; DNA; DNA damage; Endocrinology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002109973,0.0007026085,0.0004246706,0.001212208,0.0003395815,0.000416999,0.0007082212,0.000871071,0.00428185],"category_scores_gemma":[0.0004613448,0.0004545353,0.0005106508,0.0004415399,0.00068435,0.0002559088,0.0005463173,0.0009130855,0.0006306481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005573778,"about_ca_system_score_gemma":0.0004493701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001493427,"about_ca_topic_score_gemma":0.002068549,"domain_scores_codex":[0.9996457,0.00005940217,0.00005792129,0.00008532232,0.00009537847,0.00005627153],"domain_scores_gemma":[0.9991642,0.0003170181,0.0001845746,0.0001349267,0.0000281836,0.0001710101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001711161,0.00003220142,0.0002450962,0.0000171694,0.00001620947,0.000347585,0.00002131118,0.0001011959,0.9976854,0.0003958427,0.00003110837,0.0009356427],"study_design_scores_gemma":[0.00003435516,0.000211116,0.003564099,0.000005856682,0.00006302961,0.001227049,0.0000393927,0.001144313,0.9913749,0.0002093587,0.002111664,0.00001493686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897557,0.001132636,0.005367003,0.0002211302,0.00008182926,0.00003537131,0.0008573682,0.0003674569,0.002181499],"genre_scores_gemma":[0.9939666,0.0004638334,0.001452631,0.00004849775,0.00001708368,0.00002088203,0.0003675286,0.0001069742,0.003555995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00428185,"threshold_uncertainty_score":0.01432419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008165133723031619,"score_gpt":0.2234796840666694,"score_spread":0.2153145503436378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}