{"id":"W1997464162","doi":"10.1038/sj.bjc.6603010","title":"Inhibition of endosomal sequestration of basic anticancer drugs: influence on cytotoxicity and tissue penetration","year":2006,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Bafilomycin; Cytotoxicity; Endosome; Pharmacology; Chloroquine; Doxorubicin; Clonogenic assay; Chemistry; Mitoxantrone; Cancer research; Biology; Apoptosis; Chemotherapy; Cell; Immunology; Biochemistry; In vitro; Autophagy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001913089,0.00007765913,0.000279022,0.00008404687,0.00003020112,0.0000121005,0.0000292673,0.00006563304,0.00005593668],"category_scores_gemma":[0.0000158631,0.00007878339,0.00005515634,0.0001140237,0.00009568791,0.0001934342,0.000002772073,0.0001385191,2.154412e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005261555,"about_ca_system_score_gemma":0.0001678394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005424439,"about_ca_topic_score_gemma":0.0006710215,"domain_scores_codex":[0.9988708,0.00002332355,0.0005037914,0.00009712087,0.0004051235,0.00009977294],"domain_scores_gemma":[0.9991364,0.00001892598,0.0004019242,0.00005403578,0.0003392792,0.00004942091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004719387,0.0001837979,0.01756853,0.0003222762,0.00003350848,0.0001414856,0.0001203677,0.000432151,0.9615354,0.0005938329,0.00006346551,0.01853325],"study_design_scores_gemma":[0.001246472,0.0003522587,0.3823072,0.001737708,0.00007845651,0.0001341858,0.00003969969,0.00001615304,0.6134807,0.0004562773,0.00009182204,0.00005897001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996563,0.002001748,0.0003915886,0.0001252434,0.00007826832,0.0001595413,0.00003036372,0.000004800607,0.0006454585],"genre_scores_gemma":[0.9980158,0.001245941,0.0003887765,0.00005898204,0.00019943,0.000003576279,0.000006973316,0.000009469213,0.00007102408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3647387,"threshold_uncertainty_score":0.3212694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006219305817989429,"score_gpt":0.2555159567736185,"score_spread":0.2492966509556291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}