{"id":"W1997469203","doi":"10.1097/qad.0000000000000168","title":"Targeting host nucleotide biosynthesis with resveratrol inhibits emtricitabine-resistant HIV-1","year":2013,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health","keywords":"Resistance mutation; Reverse transcriptase; Biology; Resveratrol; Mutant; Molecular biology; Virology; Biochemistry; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201199,0.0003891627,0.0003776763,0.000252012,0.0001288419,0.0002646412,0.0002684557,0.0002387529,0.00129906],"category_scores_gemma":[0.0001212562,0.0001205126,0.0002726291,0.0001324675,0.0001463255,0.0001251228,0.0001317121,0.0004942623,0.0004784997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002064179,"about_ca_system_score_gemma":0.0001898895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000396686,"about_ca_topic_score_gemma":0.001535354,"domain_scores_codex":[0.9998854,0.00003058401,0.00001081735,0.00001647792,0.00002768395,0.0000289715],"domain_scores_gemma":[0.9999536,0.000009472945,0.00001248981,0.00000687546,0.000007149641,0.00001031061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004942463,0.000236212,0.0001907083,0.0001138711,0.00001918992,0.00003730498,0.00002198676,0.0001876957,0.992266,0.0000524148,0.0001307682,0.006249631],"study_design_scores_gemma":[0.0001638133,0.003272414,0.004285674,0.00002037246,0.00007958959,0.0002819014,0.00003260689,0.001140625,0.984566,0.00003709748,0.00611095,0.000008955956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918013,0.003297977,0.001769711,0.0001340263,0.00006580152,0.00008960091,0.0003384147,0.0001674087,0.002335737],"genre_scores_gemma":[0.9918947,0.002305602,0.002662303,0.00007633865,0.00002592629,0.00005374661,0.000702419,0.00002476132,0.002254338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129906,"threshold_uncertainty_score":0.004345775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006636254504442668,"score_gpt":0.2071802614527651,"score_spread":0.2005440069483224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}